Pan-cancer analysis reveals the relationship between RCSD1 immune infiltration and clinical prognosis in human tumors

Abstract

BackgroundRCSD1 is a cytoskeletal regulator that has been confirmed to undergo genetic mutations in hematological tumors, but the mechanisms of RCSD1 in pan-cancer and its impact on patient prognosis have not been studied.MethodsUsing TCGA, GEPIA, UALCAN, Kaplan-Meier plotters, Linkedomics, String, cBioPortal, TISIDB, TCIA and TIMER database methods, we investigated the expression of RCSD1 in human tumors and its relationship to clinical prognosis, functional analysis of co-expression networks, mutation status, and immune infiltration in cancers, especially lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).ResultsThe expression of RCSD1 is low in most tumors compared with normal tissues, and its high expression is associated with good patient survival. The RCSD1 co-expression network is mainly involved in the regulation of immune response. In human cancer, RCSD1 plays an important role in the tumor microenvironment (TME) and is significantly associated with the expression of immune infiltrating cells (TIL) in lung cancer.ConclusionsAs a prognostic biomarker of generalized cancer, RCSD1 is associated with immune infiltration.

Integrated Single-cell and Transcriptome Sequencing Analyses Identified PREX1 as an Immune-related Prognostic Biomarker for Liver Hepatocellular Carcinoma

“…Our results revealed that PREX1 was positively correlated with KCTD12, HEG1, RASSF2, FMNL3 and RCSD1, with the most significant correlation with RCSD1. Previous research has demonstrated that RCSD1 is positively related to infiltrating macrophages in lung cancer 30 . FMNL3 play a critical role in the recruitment of TILs and inflammatory tumor microenvironment 31 .…”

Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis

“…Several of our identified genes are related to the immune response in various cancer types, including PDAC. For example, both CD37 and RCSD1 are linked to recruitment of anti-tumour immune cells and improved prognoses [ 91 , 92 ]. ITK is implicated in immune checkpoint process [ 93 ], C1R is an immunosuppressive complement effectors protein [ 94 ] and IL7R regulates in lymphocyte development [ 95 ].…”