Pan-cancer analysis reveals an immunological role and prognostic potential of PXN in human cancer

Abstract

Paxillin (PXN) is a protein involved in numerous physiological processes, and its presence is closely related to the occurrence and development of many types of tumors. However, no studies have analyzed PXN from a pancancer perspective. We analyzed PXN expression, immune cell infiltration, prognosis, and biological function across different types of tumors included in The Cancer Genome Atlas and Gene Expression Omnibus datasets. The results showed that expression of PXN varies in different tumors. Expression of PXN strongly correlated with prognosis in patients with tumors; higher PXN expression usually was linked to poor overall and diseasefree survival. Expression of PXN in breast invasive carcinoma and lymphoid neoplasm diffuse large B-cell lymphoma was related to the degree of CD8+ T-cell infiltration, and infiltration of cancer-associated fibroblasts, such as kidney renal papillary cell carcinoma and brain lower-grade glioma, was also observed in other tumors. The results of pan-cancer analysis showed that abnormal PXN expression was related to poor prognosis, immune infiltration, and protein phosphorylation in different tumor types. Therefore, the PXN gene may become a potential biomarker of clinical tumor prognosis.

N6-Methyladenosine Methylation Regulator RBM15 is a Potential Prognostic Biomarker and Promotes Cell Proliferation in Pancreatic Adenocarcinoma

“…Pan-cancer analysis focuses on studying alterations in DNA, RNA and protein levels in different human tumor types to reveal genes associated with tumor development, which is important for cancer prevention and improving patient survival ( Chen et al, 2021 ; Lu et al, 2021 ). As an epigenetic regulatory molecular, RNA N6-methyladenosine plays a crucial role in the development and progression of cancer ( Wang et al, 2018a ).…”

The Inflamm-Aging Model Identifies Key Risk Factors in Atherosclerosis

“…The network markers indicated that endothelium, oxidative stress, and inflammation have important roles in atherosclerosis; the top-ranked genes (by degree) and their corresponding functions are shown in Table 4 ( Yang et al, 2000 ; Zhang, 2013 ; Schisler et al, 2015 ; Mezzadra et al, 2017 ; Zheng et al, 2017 ; Guan et al, 2018 ; Lan et al, 2020 ; Nie et al, 2020 ; Zheng et al, 2020 ; Chen et al, 2021a ; Cao et al, 2021 ; Covarrubias et al, 2021 ; Liu et al, 2021 ; Wang et al, 2021 ; Zheng et al, 2021 ). For example, the gene with the largest degree was PXN, which encodes a cytoskeleton protein.…”

Prognostic implications of PPL expression in ovarian cancer

“…PXN, as an important part of the focal adhesion complex, was correlated with poor clinical outcomes in patients with tumors [ 27 ]. Chen et al [ 28 ] reported that abnormal PXN expression was related to poor prognosis, immune infiltration, and protein phosphorylation in different tumor types. Upregulated PXN expression was linked to shorter OS in OV from public data platform.…”