Pan‐cancer analysis of the oncogenic role of HNRNPR in human tumors

Abstract

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are potential cancer biomarkers. Little is known about the role of HNRNPR, an essential member of the hnRNP family, in human tumours. This study aims to explore the potential value of HNRNPR across cancers, based on The Cancer Genome Atlas (TCGA). The expression level, mutation, DNA methylation, phosphorylation status, survival status, pathological stage, tumor mutation burden (TMB), microsatellite instability (MSI), immune cell infiltration, and immune signature related to HNRNPR were analyzed. HNRNPR expression level was increased in several types of cancer and was associated with poor prognosis, especially in liver hepatocellular carcinoma (LIHC). HNRNPR was also correlated with antitumour immunity, and associated with TMB, MSI, and immune cell activation status across cancers. Furthermore, nomograms were established to predict the prognosis of LIHC, based on HNRNPR and other clinical characteristics. Functional enrichment analysis showed the mechanisms of HNRNPR‐mediated LIHC progression. Loss‐of‐function experiments demonstrated that inhibition of HNRNPR could remarkably suppress hepatocellular carcinoma (HCC) cell proliferation, migration, invasion, and Epithelial‐Mesenchymal Transition abilities. Our study offers a comprehensive understanding of the oncogenic roles of HNRNPR across different tumours, and demonstrates that HNRNPR might foster the proliferation, migration, and invasion abilities of HCC cells.

Covalent Interactions of Anthocyanins with Proteins: Activity-Based Protein Profiling of Cyanidin-3-O-glucoside

“…53 SYNCRIP is related to the resistance mechanism of androgen receptor targeted therapy in prostate cancer, 51 and HNRNPR is a potential cancer biomarker. 54 This means that the design and development of covalent drugs using anthocyanin structures as lead compounds may become a new direction in related fields. The unique electron-deficient oxonium structure has great potential as a covalent binding fragment in the fields of chemical proteomics and new drug design.…”

“…There are also reports that bisphenol A significantly down-regulates the expression of SNRPC and HNRNPU genes in adolescent mouse testes . SYNCRIP is related to the resistance mechanism of androgen receptor targeted therapy in prostate cancer, and HNRNPR is a potential cancer biomarker . This means that the design and development of covalent drugs using anthocyanin structures as lead compounds may become a new direction in related fields.…”