Pan-cancer analysis of DNMT3A as a robust prognostic biomarker to predict the immunotherapy response
Xiaoyan Su,
Junzhe Liu,
Zewei Tu
et al.
Abstract:Background
DNA methyltransferase 3A (DNMT3A) is essential for de-novo methylation and cell development. Recent studies have shown that dysregulation of methylation regulated by DNMT3A is highly implicated in cancer progression. However, the regulatory roles of DNMT3A in various cancers are not completely clear and need further investigation.
Methods
The RNA-seq data in The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression databases (GTEx) are the source of this study. Western blot assays were per… Show more
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