Palpation Thyroiditis (Multifocal Granulomatous Folliculitis)

Carney, J. Aidan; Moore, Samantha; Northcutt, Robert C.; Woolner, Lewis B.; Stillwell, G. Keith

doi:10.1093/ajcp/64.5.639

Cited by 69 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The presence of MGCs in PTC does not appear to be related to the phenomenon of "palpation" thyroiditis (multifocal granulomatous thyroiditis), because this condition is also associated with degenerative and inflammatory changes in the adjacent follicular epithelium. 6 Finally, the presence of MGCs in these cases does not correlate with a prior FNAB, since 43% of the patients in this series did not have a biopsy before definitive surgery.…”

Section: Discussionmentioning

confidence: 72%

Multinucleate Giant Cells in Papillary Thyroid Carcinoma:A Morphologic and Immunohistochemical Study

Guiter

DeLellis

1996

Am J Clin Pathol

View full text Add to dashboard Cite

Multinucleate giant cells (MGCs) occur in a variety of inflammatory, hyperplastic, and neoplastic thyroid disorders. They also have been recognized as a feature of papillary thyroid carcinoma (PTC), particularly in fine-needle aspiration biopsies (FNAB). However, the origin of the MGCs and their comparative frequencies in histologic and cytologic preparations have not been established. Therefore, histologic sections from 76 cases of PTC were examined and immunohistochemical analyses for epithelial and histiocytic markers were performed. Giant cells were identified in histologic sections of 35 cases (46%) of PTC. In cytologic preparations, MGCs were identified in 12 of 22 cases (55%).Multinucleate giant cells (MGCs) occur in a variety of inflammatory, hyperplastic, and neoplastic conditions of the thyroid gland, including Hashimoto's disease, multinodular goiter, follicular adenoma, and subacute thyroiditis. ' These cells have also been recognized as a distinctive feature of papillary thyroid carcinoma (PTC) in fine-needle aspiration biopsies (FNAB).2 However, the frequency of MGCs in routine histopathologic material and their origin (epithelial versus histiocytic) have not been established. Therefore, the goals of this investigation were to determine the frequency of MGCs in routine histologic sections and cytologic preparations of PTC and to determine their origin using immunohistochemical markers of epithelial and histiocytic differentiation. 3,4 The patients included 54 females and 22 males with a mean age of 44.52 years (range 16-87 years). Hematoxylin-and-eosin-stained sections were reviewed from all cases independently by both authors. An average number of four slides were examined per case (range 2-6 slides), and the presence or absence of MGCs was recorded. All sections were examined at medium power (X100) to determine whether MGCs were present. In those cases with MGCs, the sections were examined at high power (X400), and the numbers of MGCs were counted in at least 50 high power fields in areas of highest MGC density. MATERIALS AND METHODS SeventyThe presence of MGCs was assessed in 22 additional fine-needle biopsies of PTC. The cytologic preparations were examined at medium power (X100), and MGCs were recorded as being present or absent.In 10 cases of PTC containing MGCs, additional sections were stained for a variety of markers of epithelial and histiocytic differentiation. Antibodies against the following antigens were used: thyroglobulin and lysozyme (Dako Labs, Carpinteria, CA, dilution 1:750); a-1-antichymotrypsin (Dako Labs, Indianapolis, IN, dilution 1:800); KP1/CD68 (Dako Labs, dilution 1:50); AEI/ AEIII keratins (Boehringer-Mannheim, Indianapolis, IN, dilution 1:100). Immunohistochemical stains were performed on 5jt thick paraffin sections of formalin-fixed tissue. The sections were deparaffinized in xylene and hydrated in graded alcohols. They were then incubated in 765

show abstract

Section: Discussionmentioning

confidence: 72%

Multinucleate Giant Cells in Papillary Thyroid Carcinoma:A Morphologic and Immunohistochemical Study

Guiter

DeLellis

1996

Am J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…They have also been reported in a broad spectrum of diseases ranging from palpation thyroiditis to drug reactions such as fenitoins, postsurgical reactions, postradionucleotide scan, follicular neoplasms, Hashimoto's thyroiditis, and others. [2][3][4][5][6][7][8] Osteoclast-like giant cells have been reported in rare cases of anaplastic carcinomas. 9,10 This study was undertaken to see whether the quantity and/or quality, i.e., the morphologic characteristics of MNGCs as seen on fine-needle aspiration (FNA) of thyroid nodules, can help in the differential diagnosis of these diagnostic possibilities.…”

mentioning

confidence: 99%

Multinucleated Giant Cells in Fine-Needle Aspiration of Thyroid Nodules: Their Diagnostic Significance

et al. 1999

View full text Add to dashboard Cite

Multinucleated giant cells (MNGCs) are reported in many thyroid lesions. This study examines whether their quantity and quality can help in the differential diagnosis. All fine‐needle aspirations (FNAs) of the thyroid with a “significant” number of MNGCs were reviewed from 1995 –1998. There were 23 cases (<1% of thyroid FNAs): 8 papillary carcinomas (PC), 4 subacute thyroiditis (ST), 3 granulomas, 7 adenomatous goiters (AG), and one Hurthle‐cell adenoma (HA). MNGCs with dense cytoplasm were seen exclusively in PC, ST, and granulomas. They had angulated shapes. They were most numerous, largest, and with the highest number of nuclei in ST and granulomas. MNGCs with foamy cytoplasm were seen in AG and HA and 80% of the other cases (PC, ST, and granulomas). In PC, rare MNGCs had intranuclear inclusions and grooves. The accompanying cell population was characteristic of each disease. The quantity and quality of MNGCs in thyroid FNA may be helpful in narrowing the differential diagnosis. Diagn. Cytopathol. 1999;21:307–312. © 1999 Wiley‐Liss, Inc.

show abstract

“…Palpation thyroiditis, which results from minor trauma, may also yield multinucleated giant cells; however, this condition is less likely to undergo fine needle aspiration since the lesion is usually asymptomatic and the findings usually incidental in histologic examination. 3 Rarely are granulomatous reactions of the thyroid due to mycobacterial or fungal infections encountered by fine needle aspiration.…”

Section: Resultsmentioning

confidence: 99%