Palpable parathyroid adenomas presenting as clinical solitary thyroid nodules and cytologically as follicular thyroid neoplasms

Weymouth, Michael; Serpell, Johnathan W; Chambers, David

doi:10.1046/j.1445-2197.2003.02636.x

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…Parathyroid cysts can mimic a thyroid mass, as in our case, with concomitant disease of both thyroid and parathyroids not uncommon and a potential source of confusion 19 . Bentrem et al report parathyroid adenomas or cysts to be present concomitantly with multinodular goitre in 18% of cases, 20 whereas in another report significant thyroid pathology was seen in as many as 25% of cases of PHPT 21 .…”

Section: Discussionmentioning

confidence: 54%

Giant Functioning Parathyroid Cyst Presenting as a Retrosternal Goitre

McKay

Morgan

et al. 2007

ANZ Journal of Surgery

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Parathyroid cysts are rare and even more rarely cause a neck mass resembling a goitre. Such large parathyroid cysts may involve the mediastinum, growing to a sufficient size to produce symptoms related to obstruction, and if functioning, primary hyperparathyroidism. Parathyroid cysts should be considered in the list of differential diagnoses of anterior neck masses to allow for appropriate preoperative investigation to avoid unnecessary confusion at the time of operation. We report a case where a functioning parathyroid cyst presented as a retrosternal goitre to emphasize the potential pitfalls associated with their diagnosis and management.

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Section: Discussionmentioning

confidence: 54%

Giant Functioning Parathyroid Cyst Presenting as a Retrosternal Goitre

McKay

Morgan

et al. 2007

ANZ Journal of Surgery

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“…FNA cytology of the parathyroid might be misdiagnosed as Hürthle cell associated lesions of thyroid such as Hürthle cell thyroid neoplasm [9, 15–17]; adenomatous thyroid nodules with Hürthle cell change; or chronic lymphocytic thyroiditis [18] because they might share some cytomorphologic similarities such as follicular structures, colloid-like material in the background [9]. Moreover, the presence of oncocytic cells and naked nuclei of chief cells in parathyroid cytologic specimen can be mimicking Hürthle cells and lymphocytes, respectively [19, 20].…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration Cytology of Parathyroid Carcinoma Mimic Hürthle Cell Thyroid Neoplasm

Sriphrapradang

Sornmayura

Chanplakorn

et al. 2014

Case Reports in Endocrinology

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Background. Fine-needle aspiration (FNA) can cause misdiagnosis of cytomorphological findings between parathyroid and thyroid lesions. Case Presentation. A 31-year-old man presented with a palpable neck mass on the right thyroid lobe. FNA cytology was reported as intrathyroidal lymphoid hyperplasia. After 5 years, repeated FNA was done on the enlarged nodule with result of Hürthle cell lesion. Prior to right lobectomy, laboratories revealed elevated serum calcium and parathyroid hormone (PTH). Careful history taking revealed chronic knee pain and ossifying fibroma at the maxilla. Ultrasonography showed a 2.8 cm mass inferior to right thyroid lobe. Pathology from en bloc resection was parathyroid carcinoma and immunohistochemical study revealed positivity for PTH. Genetic analysis found somatic mutation of CDC73 gene in exon1 (c.70delG) which caused premature stop codon in amino acid 26 (p.Glu24Lysfs*2). The final diagnosis was hyperparathyroidism-jaw tumor syndrome. Conclusions. FNA cytology of parathyroid can mimic thyroid lesion. It is important to consider and correlate the entire information from clinical history, laboratory, imaging, and FNA.

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“…All the patients in our series had hyper functioning tumours. Fine needle aspiration cytology (FNAC) is not very helpful because they often present as a solitary thyroid nodule and mimic follicular thyroid neoplasms and was not used in our series [5]. No preoperative test reliably distinguishes parathyroid cancer from benign primary hyperparathyroidism.…”

Section: Discussionmentioning

confidence: 99%