Palpable migratory arciform erythema. Clinical morphology, histopathology, immunohistochemistry, and response to treatment

Abeck, D.

doi:10.1001/archderm.133.6.763

Cited by 8 publications

(23 citation statements)

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“…In one previous study [35], monoclonal findings in JLIS were demonstrated in 100% of the cases, while other, more recent studies demonstrated polyclonal T-cell populations in the disease [9, 21, 36]. In our study, we found polyclonal gene rearrangement patterns of the TCR-γ gene in the overwhelming majority of the skin specimens and of the peripheral blood samples.…”

Section: Commentsupporting

confidence: 62%

“…palpable migratory arciform erythema. This disease has only very rarely been reported in the literature [9, 10, 21, 22]; in addition, it is impossible to differentiate it clinically, histologically or immunohistologically from JLIS [21, 22]. In our study, overlapping presentation of the disease with both papules and plaques and elevated annular erythema in the same localisation as well as concomitant involvement of the face and trunk indicate that palpable migratory arciform erythema is not a unique entity, but a special clinical presentation of JLIS.…”

Section: Commentmentioning

confidence: 99%

“…lupus erythematosus tumidus [7], or of the plaque type of polymorphous light eruption [8]. In addition, some authors have described JLIS localising solely on the trunk and have named it palpable migratory arciform erythema postulating that it might represent a unique disease entity [9, 10]. Here, we present a hitherto unreported cohort of 34 patients with JLIS in whom we performed clinical, immunohistochemical and molecular studies in order to thoroughly re-evaluate the disease.…”

Section: Introductionmentioning

confidence: 99%

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Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

et al. 2003

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Background: Jessner’s lymphocytic infiltration of the skin (JLIS) is a clinically and histologically distinct disease entity. Conflicting results have been reported concerning its differentiation from cutaneous lupus erythematosus and polymorphous light eruption, its relationship to palpable migratory arciform erythema and its classification as a B-cell or a CD4+ T-cell lymphoproliferative disease. Objective: Our study was performed in order to re-evaluate JLIS clinically and by immunohistochemical and molecular analyses. Methods: Stringent inclusion/exclusion criteria were used to collect a cohort of 34 patients with JLIS that did not overlap with lupus erythematosus or polymorphous light eruption. Clinical data were analysed, and immunohistochemical and molecular studies were performed including TCR-γ PCR GeneScan software analysis of tissue and peripheral blood samples. Results: In the majority of the patients, the lesions consisted only of papules and plaques while in 12% annular lesions were also seen. The lesions were found on the face (38%), on the trunk and arms (50%) or at both sites (12%). Immunohistochemical analyses revealed a clear predominance of T cells in all patients, and of CD8+ T cells in 77% of the patients. As judged by TCR-γ PCR GeneScan analysis, 98 and 79% of the tissue and peripheral blood samples, respectively, showed a polyclonal T-cell population; identical T-cell clones were not detected concomitantly in both the skin and the peripheral blood of the same patient. Conclusions: JLIS occurs at 2 major predilection sites, that is the face and trunk. Therefore introduction of palpable migratory arciform erythema as a separate entity is not justified. The lymphoid infiltrates are dominated immunohistochemically by CD8+ T cells that do not show clonality on molecular analysis. Thus, JLIS represents a characteristic CD8+ polyclonal reactive skin condition.

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Section: Commentsupporting

confidence: 62%

Section: Commentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

et al. 2003

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“…1 Since its original description, several case reports showing identical clinical and histologic features have been published. [2][3][4][5] The main features of those cases are summarized in Table 1.…”

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confidence: 99%

“…The lesions show centrifugal progression, sometimes growing to a diameter of 20 cm or more. [2][3][4][5] On histology, dense superficial and deep perivascular and periadnexal dermal infiltrates are predominantly composed of lymphocytes. Neither epidermal involvement nor follicular center formation have been observed.…”

mentioning

confidence: 99%

Palpable arciform migratory erythema in an HIV patient, a CD8⁺ pseudolymphoma

Muche¹,

Toppe²,

Sterry³

et al. 2004

J Cutan Pathol

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Cutaneous pseudolymphoma—A review on the spectrum and a proposal for a new classification

2019

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Cutaneous pseudolymphomas (PSLs) belong to a group of lymphocytic infiltrates that histopathologically and/or clinically simulate lymphomas. Different causative agents (e.g., Borrelia sp., injected substances, tattoo, arthropod bite) have been described, but in many cases no cause can be identified, hence the term idiopathic PSL. Clinicopathological correlation is important to make the diagnosis. Four main groups of cutaneous PSL can be distinguished based on histopathologic and/or clinical presentation: (a) nodular PSL; (b) pseudo-mycosis fungoides (pseudo-MF) and simulators of other CTCLs; (c) other PSL (representing distinct clinical entities); and (d) intravascular PSL. This article gives an overview of the histopathologic and clinical characteristics of cutaneous PSLs and proposes a new classification.

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Palpable migratory arciform erythema. Clinical morphology, histopathology, immunohistochemistry, and response to treatment

Cited by 8 publications

References 0 publications

Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

Palpable arciform migratory erythema in an HIV patient, a CD8⁺ pseudolymphoma

Cutaneous pseudolymphoma—A review on the spectrum and a proposal for a new classification

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Palpable migratory arciform erythema. Clinical morphology, histopathology, immunohistochemistry, and response to treatment

Cited by 8 publications

References 0 publications

Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

Palpable arciform migratory erythema in an HIV patient, a CD8+ pseudolymphoma

Cutaneous pseudolymphoma—A review on the spectrum and a proposal for a new classification

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Palpable arciform migratory erythema in an HIV patient, a CD8⁺ pseudolymphoma