“…The RCTs were conducted by authors in Egypt, 22 the Netherlands, 23 Japan, 24,26,31,35 India, 25,27 China, [28][29][30] Korea, 34 the US and multiple countries in Latin America, Western and Eastern Europe, and Russia. 32,33 Two RCTs were published in 2021, 22,23 1 in 2020, 24 2 in 2019, 25,26 3 in 2018, [27][28][29] and 4 in 2016. 31,32,34,35 Four RCTs were designed to test the noninferiority of palonosetron compared to ondansetron 23,27,32 or to granisetron.…”