Palmoplantar Pustulosis: an Autoimmune Disease Precipitated by Smoking?

Hagforsen, Eva; Mustafa, A.; Lefvert, Ann‐Kari; Nordlind, Klas; Michaëlsson, G

doi:10.1080/000155502320624069

Cited by 55 publications

(49 citation statements)

References 3 publications

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“…Occupational physicians can play an active role in smoking prevention and cessation and must provide their smoking employees incentive, guidance and intervention to help them discontinue this habit. Tobacco smoking is known to influence various inflammatory skin diseases [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26]. An association between smoking and HE has been postulated [16,19,22,23,24,25,26] and the present findings underscore that smoking has a negative impact on work-related HE.…”

Section: Discussionsupporting

confidence: 58%

“…In addition to its well-known long-term complications, smoking is also known to influence various inflammatory skin diseases. Thus, smoking has been shown to be a risk factor for developing lupus erythematodes [10,11,12], palmoplantar pustulosis [13,14,15] and, to some extent, also psoriasis [16,17]. Numerous studies have linked cigarette smoking with delayed wound healing and a number of wound-related complications [18].…”

Section: Introductionmentioning

confidence: 99%

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Does Smoking Have a Significant Impact on Early Irritant Hand Dermatitis in Metal Workers?

Kütting

Uter²,

Weistenhöfer³

et al. 2011

Dermatology

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Background: Although they know the long-term complications of smoking, many smokers require additional motivation for entering a smoking cessation programme. At the same time, smoking is considered a possible promoting factor for various skin diseases. Objective: The present study assesses the impact of smoking on occupational hand dermatitis in a high-risk population. Material and Methods: 1,355 metal workers, 97.3% of them shift workers, took part in a standardized interview and a dermatological examination of their hands. A subgroup of 1,020 males was willing to be followed-up for 1 year. Of those, 78.3% could be included in the final assessment. Results: Compared to the general German adult population the percentage of smokers was increased (41.7% at baseline). Probably due to self-selection bias and to a higher drop-out rate, the proportion of smokers was significantly lower at follow-up. Compared to nonsmokers, smokers had significantly higher score values for both erythematous lesions and vesicles. Conclusion: The present data might give additional support for occupational physicians or dermatologists to convince workers to quit smoking.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Does Smoking Have a Significant Impact on Early Irritant Hand Dermatitis in Metal Workers?

Kütting

Uter²,

Weistenhöfer³

et al. 2011

Dermatology

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show abstract

“…21 Ten patients (43%) with eczematiform lesions and 28 patients (45%) with psoriasiform lesions were smokers. Palmoplantar lesions, which can be triggered by smoking, 22 were observed in 22 patients of whom 15 (68%) were smokers. This close relationship has also been observed for other forms of psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Severe Skin Lesions Cause Patients With Inflammatory Bowel Disease to Discontinue Anti–Tumor Necrosis Factor Therapy

Rahier

Buche

Peyrin-Biroulet

et al. 2010

Clinical Gastroenterology and Hepatology

156

166

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BACKGROUND & AIMS:Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-α therapies. We assessed clinical characteristics, risk factors, and outcomes of skin disease in patients with inflammatory bowel diseases that presented with psoriasiform and eczematiform lesions induced by anti-TNF-α agents. METHODS: We studied 85 patients (69 with Crohn's disease, 15 with ulcerative colitis, and 1 with indeterminate colitis; 62 women) with inflammatory skin lesions (62 psoriasiform and 23 eczematiform lesions). RESULTS: Twenty-four patients had a history of inflammatory skin lesions and 15 had a familial history of inflammatory skin disease. Locations of eczematiform lesions varied whereas scalp and flexural varieties were mostly psoriasiform. Skin lesions emerged but inflammatory bowel disease was quiescent in 69 patients following treatment with any type of anti-TNF-α agent (60 with infliximab, 20 with adalimumab, and 5 with certolizumab). Topical therapy resulted in partial or total remission in 41 patients. Patients with psoriasiform lesions that were resistant to topical therapy and that changed anti-TNF-α therapies once or twice developed recurring lesions. Overall, uncontrolled skin lesions caused 29 patients to stop taking TNF-α inhibitors. CONCLUSIONS: Inflammatory skin lesions following therapy with TNF-α inhibitors occurred most frequently among women and patients with a personal or familial history of inflammatory skin disease; lesions did not correlate with intestinal disease activity. Recurring and intense skin lesions caused 34% of patients in this study to discontinue use of anti-TNF-α agents.

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“…In addition, fibroblast migration into lesional skin is inhibited (13,14). Smoking has been suspected to be a risk factor for skin diseases such as lupus erythematosus (15,16), palmoplantar pustulosis (17,18), psoriasis (19,20), and hidradentis suppurativa (21). In two of these diseases, hidradentis suppurativa and palmoplantar pustulosis, the data have indicated that the cessation of smoking may improve the disease (22,23).…”

mentioning

confidence: 99%

Tobacco smoking and hand eczema – is there an association?

et al. 2015

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SummaryBackground. Numerous risk factors have been suggested for hand eczema. This systematic review evaluates the association between tobacco smoking and hand eczema. Objective. To review the literature systematically on the association between smoking and hand eczema. Methods. The PubMed and EMBASE databases were searched up to 27 January 2015 for articles on the association between tobacco smoking and hand eczema, including human studies in English and German only. Experimental studies, studies on tobacco allergy, case reports, reviews and studies on second-hand smoking were excluded. Results. Twenty articles were included. Among studies in occupational settings, three of seven found a statistically significant positive association between tobacco smoking and hand eczema prevalence rate, as did four of eight population-based studies. The association was stronger for studies in occupational settings than for population-based studies. No studies reported tobacco to be a clear protective factor for hand eczema. Two of five studies regarding severity found a positive association between smoking and hand eczema severity. Conclusion. Overall, the data indicate that smoking may cause an increased frequency of hand eczema, particularly in high-risk occupations. However, data from studies controlling for other risk factors are conflicting, and few prospective studies are available. Studies controlling for other risk factors are needed, and information regarding the diagnosis of subclasses of hand eczema, as well as severity, may be important.

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Palmoplantar Pustulosis: an Autoimmune Disease Precipitated by Smoking?

Cited by 55 publications

References 3 publications

Does Smoking Have a Significant Impact on Early Irritant Hand Dermatitis in Metal Workers?

Does Smoking Have a Significant Impact on Early Irritant Hand Dermatitis in Metal Workers?

Severe Skin Lesions Cause Patients With Inflammatory Bowel Disease to Discontinue Anti–Tumor Necrosis Factor Therapy

Tobacco smoking and hand eczema – is there an association?

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