Palmoplantar lichen planus‐like lupus erythematosus keratoderma: an underrecognized and distinctive cutaneous manifestation of systemic or subacute lupus erythematosus

Abstract

BP. 6,7 Our study showed a direct positive correlation between TARC levels and disease activity scores in BP patients for the first time. In particular, TARC levels correlated with urticaria/ erythema scores of the BPDAI score; this may reflect the inflammatory pathogenic response in BP similar to the Th2 response in atopic dermatitis. 8 Notably, a longitudinal analysis of our cases showed that TARC levels sensitively reflected skin flare-ups and were upregulated before the increase in anti-BP180 Ab levels in some cases. Serum TARC levels sharply reflect disease activity in BP with high sensitivity and across a wide range of changes. In conclusion, these results suggest that in clinical practice, TARC levels could usefully predict disease activity in patients with BP.

A Case of Palmoplantar Keratoderma in the Constellation of Connective Tissue Diseases

“…Antisynthetase syndrome could be a close differential diagnosis in our case, but the absence of antisynthetase antibodies and the presence of definitive histopathologic findings ruled out antisynthetase syndrome. The association of palmoplantar keratoderma has been described with the presence of anti-PM/Scl antibodies [5] and is also reported to be a rare entity in SLE, especially in patients positive for anti-Ro/SSA antibodies [6]. Anti-PM/Scl Ab are known to be associated with (in order of descending frequency) inflammatory myopathy/overlap syndrome/systemic sclerosis/undifferentiated CTD.…”