Palmar Eccrine Hidradenitis Secondary to Trauma from Computer Gaming in an Adolescent After Bone Marrow Transplantation

Lee, Lynette Ying; Koh, Mark Jean‐Aan

doi:10.1111/pde.13224

Cited by 4 publications

(6 citation statements)

References 5 publications

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“…Mechanical stresses induced by skin‐to‐skin rubbing, such as tension, strain and friction, exacerbate HS . Anecdotal case reports describe HS lesions developing in unusual body areas after mechanical stress and trauma . Despite these reports, the underlying mechanism(s) for why mechanical stress exacerbates HS symptoms are not entirely clear.…”

Section: Introductionmentioning

confidence: 99%

“…[7] Anecdotal case reports describe HS lesions developing in unusual body areas after mechanical stress and trauma. [7][8][9] Despite these reports, the underlying mechanism(s) for why mechanical stress exacerbates HS symptoms are not entirely clear.Skin responds to and resists mechanical stress through its cell-cell adhesions. Cell-cell adhesions are critical to maintain the structural integrity, tensile strength and barrier function of skin.Specifically, both adherens junctions (AJs) and desmosomes are mechanosensitive junctions responsible for sensing and reacting to mechanical forces by both altering the cytoskeleton and modulating downstream signalling cascades.…”

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confidence: 99%

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confidence: 99%

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E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

Nelson

Cong

Gettle

et al. 2019

Experimental Dermatology

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Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease affecting the pilosebaceous units in the axilla, groin and buttocks. While the pathogenesis of HS is not clear, mechanical stress exacerbates HS. In this study, we aimed to determine whether intracellular adhesive junctions may be aberrant in HS patient skin. Strikingly, we observed loss of E‐cadherin and p120ctn protein expression, two key adherens junction proteins, in ~85% of HS severe skin lesions. Moreover, loss of protein expression was apparent in non‐lesional skin from HS patients and the degree of loss positively correlated with HS Hurley Stage of disease. E‐cadherin expression was unaltered in other inflammatory skin conditions including chronic wound epithelium, atopic dermatitis, and acne vulgaris compared with healthy skin suggesting that its loss may be uniquely relevant to HS pathogenesis. A complete loss of α‐catenin, β‐catenin and ZO‐1 was not observed; however, some cytoplasmic staining of the catenins was noted in HS epithelium. We also demonstrated diminished desmosome size in HS lesional skin. Overall, our data suggested that loss of adherens junction proteins and diminished desmosome size in HS skin contributes to the skin's inability to withstand mechanical stress and provides rationale as to why mechanical stress exacerbates HS symptoms.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

Nelson

Cong

Gettle

et al. 2019

Experimental Dermatology

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“…The excessive gaming in which our patients were engaged, many times that of the average American teen, has many potential consequences, of them being physical injury of the hands. Other reported injuries related to excessive gaming include de Quervain's tenosynovitis of the thumb (“gamer's thumb” or “nintendonitis”), punctate hemorrhage of the fingertips (“Playstation fingertip”), and rarely palmar eccrine hidradenitis, and are associated with excessive and strenuous use of gaming controllers, joysticks, cell phones, and other handheld devices 15‐19 . While there are many individuals who engage in computer gaming without developing pachydermodactyly or other disorders, excessive gaming may be a risk factor for pachydermodactyly in otherwise susceptible individuals.…”

Section: Discussionmentioning

confidence: 99%

Pachydermodactyly associated with extensive computer gaming: A report of three cases

Dagrosa

Fraser

Linos

et al. 2020

Pediatric Dermatology

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Pachydermodactyly is an uncommon, progressive, nontender thickening of the fingers with prominent involvement of the proximal interphalangeal joints. Pachydermodactyly mimics inflammatory arthritis but plain film radiography is normal in this condition. Pachydermodactyly has been previously described in workers performing manual labor. Mechanical stimulation has been identified as a predisposing factor in the majority of cases. We present three cases in adolescent males arising in association with excessive computer gaming.

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“…Histology evidenced a focal neutrophilic inflammatory infiltrate surrounding the acrosyringium and eccrine sweat gland coils, consistent with palmar eccrine hidradenitis secondary to prolonged low-grade trauma. In this case too, cessation of video game playing led to spontaneous resolution of the lesions within two weeks [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Skin in the game

Kyriakou

Glentis

2021

International Journal of Pediatrics and Adolescent Medicine

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Background Following the inception of video games and the subsequent development of progressive innovations in videogame technology, many reports of videogame-related dermatologic conditions soon emerged in literature. Children and adolescents, in particular, are among the most avid consumers of online digital entertainment. Methods In an effort to better detail the impacts of these cutaneous manifestations and provide recommendations for injury prevention as it relates to video games, we performed an extensive systems-based literature review pertaining to the clinical features, etiology, diagnosis, and treatment of reported cases of dermatoses resulting from the misuse of video games. Results A literature review using PubMed, SCOPUS, Ovid MEDLINE and EMBASE was performed. Hardware implicated in the reported cases include video games consoles, personal computers, laptop computers, mobile phones and tablets. The dermatologic conditions are primarily localized to the extremities, particularly the palms and fingers. The majority are associated with repetitive friction and trauma, as well as allergic contact sensitivities. For all cutaneous manifestations induced by video gaming, early recognition and removal of the offending agent was most often described as effective in symptom resolution. Conclusions The universal use and pervasive popularity of video games for recreational purposes present an emerging dermatological concern. As videogames become increasingly advanced and immersive, various cutaneous conditions arising from intensive gaming will likely become common over time. Consequently, it is critical that dermatologists consider video games with a high index of suspicion when encountering dermatological ailments in underage patients engaging in persistent gaming behavior.

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Palmar Eccrine Hidradenitis Secondary to Trauma from Computer Gaming in an Adolescent After Bone Marrow Transplantation

Cited by 4 publications

References 5 publications

E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

Pachydermodactyly associated with extensive computer gaming: A report of three cases

Skin in the game

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