Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress

Azlina, Mohd Fahami Nur; Ibrahim, Ibrahim A.; Kamisah, Yusof

doi:10.1186/1471-230x-12-54

Cited by 27 publications

(22 citation statements)

References 31 publications

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“…Plasma or serum adrenocorticotropic hormone, CORT, adrenaline, noradrenalin, and glucose levels increase in response to WIRS in rats . It has been reported that attenuation of the stress response leads to protection against WIRS‐induced gastric mucosal lesions in rats . In the present study, any dose of DMTU pre‐administered to rats with 3 h of WIRS did not affect increases in serum CORT and glucose levels.…”

Section: Discussioncontrasting

confidence: 45%

Protective effect of N,N’‐dimethylthiourea against stress‐induced gastric mucosal lesions in rats

Ohta

Yashiro

Kobayashi

et al. 2017

Fundamemntal Clinical Pharma

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In the present study, we examined the protective effect of N,N'-dimethylthiourea (DMTU), a scavenger of hydroxyl radical (·OH), against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats. When male Wistar rats fasted for 24 h were exposed to WIRS for 3 h, gastric mucosal lesions occurred with increases in the levels of gastric mucosal myeloperoxidase (MPO), an index of tissue neutrophil infiltration, pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin 1beta), lipid peroxide (LPO), and nitrite/nitrate (NOx), an index of nitric oxide synthesis, and decreases in the levels of gastric mucosal nonprotein SH and vitamin C and gastric adherent mucus. DMTU (1, 2.5, or 5 mmol/kg) administered orally at 0.5 h before the onset of WIRS reduced the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner. Serum levels of corticosterone and glucose, which are indices of stress responses, increased in rats exposed to WIRS for 3 h, but DMTU pre-administered at any dose had no effect on these increases. These results indicate that DMTU protects against WIRS-induced gastric mucosal lesions in rats by exerting its antioxidant action including ·OH scavenging and its anti-inflammatory action without affecting the stress response.

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Section: Discussioncontrasting

confidence: 45%

Protective effect of N,N’‐dimethylthiourea against stress‐induced gastric mucosal lesions in rats

Ohta

Yashiro

Kobayashi

et al. 2017

Fundamemntal Clinical Pharma

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“…These results indicate that dietary vitamin E supplementation for the period of 4 wk does not affect the stress response via the hypothalamus-pituitary-adrenal axis or the sympathetic-adrenomedullary system in rats with 6 h of WIRS. In contrast, Aziz Ibrahim et al (18) and Mohd Fahami et al (19) have shown that when rats pre-administered a-tocopherol (60 mg/kg body weight) through oral intubation once daily for 28 d are exposed to WIRS for 3.5 h, WIRS-induced increases in plasma ACTH, corticosterone, adrenaline, and noradrenaline concentrations are reduced, although WIRS-induced gastric mucosal damage is attenuated at the same time. We have shown that the same dietary vitamin E supplementation as used in the present study attenuates gastric mucosal lesions in rats with 6 h of WIRS (30).…”

Section: Discussionmentioning

confidence: 89%

“…It has been reported that oral supplementation of vitamin E for 28 d protects against gastric mucosal damage by reducing stress response, judging from the plasma levels of stress markers such as adrenocorticotrophic hormone (ACTH), corticosterone, adrenaline, and noradrenaline in rats with 3.5 h of WIRS (18,19). It is known that exposure of rats to 6 h of WIRS increases not only the serum or plasma levels of stress markers such as ACTH, corticosterone, adrenaline, noradrenaline, and glucose levels but also serum ascorbic acid and LPO levels (9,10,17,20).…”

Section: Effect Of Dietary Vitamin E Supplementation On Liver Oxidatimentioning

confidence: 99%

Effect of Dietary Vitamin E Supplementation on Liver Oxidative Damage in Rats with Water-Immersion Restraint Stress

Ohta

Yashiro

Ohashi

et al. 2015

J Nutr Sci Vitaminol

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Water-immersion restraint stress (WIRS), which is characterized with both psychological stress and physical stress, is widely used to induce reproducible stress ulcers in experimental animals (1). Reactive oxygen species (ROS) and nitric oxide ( • NO) generation, lipid peroxidation, and neutrophil infiltration in the gastric mucosal tissue play a critical role in the pathogenesis of WIRS-induced gastric mucosal lesions (2-5). Iwai et al. (6) have reported that, in rats with 6 h of WIRS, the level of liver lipid peroxide (LPO), which is generated via ROS, increases with concomitant increases in the levels of serum LPO and liver cell damage markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activities and that pre-administration of gamazumi fruit juice or (2)-epigallocatechin gallate, each of which possesses antioxidant activity, for 2 wk attenuates all these stress-induced changes. Furthermore, the same authors have reported that not only an increase in LPO level but also decreases in superoxide dismutase (SOD) activity and reduced glutathione (GSH) level occur without changes in catalase and glutathione peroxidase activities in the liver of rats with 6 h of WIRS and that preadministration of gamazumi crude extract possessing antioxidant activity to rats with 6 h of WIRS for 2 wk attenuates the increased LPO level and the decreased SOD activity and GSH level in the liver (7). We have reported that, in the liver of rats exposed to WIRS over a 6-h period, cell damage occurs before the appearance of oxidative stress with disruption of antioxidant defense systems associated with decreased ascorbic acid (vitamin C) and GSH levels and SOD activity and enhanced lipid peroxidation, enhanced • NO generation, and neutrophil infiltration in the tissue, although the vitamin E level does not change in the liver tissue (8). We have also shown that a single pre-administration of l-ascorbic acid protects against oxidative damage in the liver of rats with 6 h of WIRS by attenuating disrupted antioxidant defense systems and enhanced lipid peroxidation, enhanced• NO generation, and neutrophil infiltration in Asaminami-ku, Hiroshima 731-0153, Japan (Received October 20, 2014) Summary We examined how dietary supplementation of vitamin E protects against liver oxidative damage in rats with water-immersion restraint stress (WIRS). Before WIRS exposure, rats received a normal diet (ND) or vitamin E-supplemented diet (VESD) (500 IU a-tocopherol/kg diet) at a mean dose of 15 g/animal/d for 4 wk. The two diet groups had serum transaminases and lactate dehydrogenase activities and adrenocorticotropic hormone, corticosterone, and glucose levels to a similar extent. VESD-fed rats had higher liver a-tocopherol concentrations and lower liver ascorbic acid, total coenzyme Q9 (CoQ9), reduced CoQ9, reduced CoQ10, and lipid peroxide (LPO) concentrations than ND-fed rats. When the two diet groups were exposed to 6 h of WIRS, the serum liver cell damage index enzyme activities incr...

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“…This occurs by enhancing the aggressive factors with severe extensive gastric damage as shown in our histological examination that can be explained by many causes. First, CRS in the present study signifi cantly increased the gastric acidity, proteolytic activity with concomitant reduction in the volume of gastric juice as compared to control group, which is likely to be due to increase in the sympatho-adrenal activity, which occurs during stress (22).…”

Section: Discussionmentioning

confidence: 92%

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

A.¹,

Aziz²,

Muralinath.E³

et al. 2017

BLL

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To assess the gastro-protective potential of the angiotensin (Ang-) (1-7) on the gastric secretion and ulceration induced by cold restraint stress (CRS) in adult male rats and the possible contribution of nitric oxide and prostaglandin E 2 . Rats were pylorically ligated and divided randomly into the following groups (8 rats each): control, cold-restraint stressed (CRS), stressed Ang-(1-7) treated, stressed L-NNA-Ang-(1-7) treated, stressed Indo-Ang-(1-7) treated groups. Our results revealed that Ang-(1-7) pre-treatment proved to be protective against development of ulcerative lesions in CRS model as evidenced by histological examination and the reduction of the ulcer index and this could be mediated through reduction of free and total acidity and pepsin concentration of gastric secretion with signifi cantly decreased lipid peroxidation and increased the gastric protective nitric oxide and prostaglandin E 2 levels. Furthermore, Ang-(1-7) pre-treatment has anti-apoptotic effect, evident by its down-regulation of the CRS induced over-expression of the gastric caspase 3. In addition, the gastro-protective effects of Ang-(1-7) were signifi cantly attenuated by co-administration with L-NNA or indomethacin. In conclusion, Ang-(1-7) can be considered a potential therapeutic agent to protect against the major clinical challenge of gastric injury resulting from stress. Nitric oxide and prostaglandin E 2 seem to contribute to the Ang-(1-7)'s gastro-protective effect (Tab. 2, Fig. 5, Ref. 35). Text in PDF www.elis.sk.

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Palm vitamin E reduces catecholamines, xanthine oxidase activity and gastric lesions in rats exposed to water-immersion restraint stress

Cited by 27 publications

References 31 publications

Protective effect of N,N’‐dimethylthiourea against stress‐induced gastric mucosal lesions in rats

Protective effect of N,N’‐dimethylthiourea against stress‐induced gastric mucosal lesions in rats

Effect of Dietary Vitamin E Supplementation on Liver Oxidative Damage in Rats with Water-Immersion Restraint Stress

Possible contribution of nitric oxide and prostaglandin in the protective effect of angiotensin (1-7) against stress induced gastric ulceration in adult male albino rats

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