Palm Tocotrienols Cause Cleavage of Poly-(Adp)-Ribose Polymerase Enzyme and Down-Regulation of Cyclooxygenase-2 Protein Level in Human Breast Cancer Cells

Loganathan, Radhika

doi:10.21894/jopr.2020.0082

Cited by 6 publications

(7 citation statements)

References 17 publications

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“…Thus, our data demonstrate that PO (particularly at higher concentrations) has the potential ability to restrain the proliferation of chronic myeloid leukaemia. This observation is consistent with previous in vitro and in vivo studies, which demonstrate that PO and its derived product have a significant role against cancer cells (Absalome et al, 2020;Loganathan et al, 2021;Sambanthamurthi et al, 2011). The underlying process of cell death caused by PO has been evaluated by some researchers.…”

Section: Growth Rates Of K562 Cells In the Presence Of Po Or/and Pbmsupporting

confidence: 92%

Antiproliferative Effects of Palm Oil in the Presence of Photobiomodulation Against K562 Cancer Cells

HEKMAT¹

2023

JOPR

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Palm oil (PO) is utilised for food such as cooking oil and non-food such as for making creams, soaps and detergents. It contains various unsaturated and saturated fats, vitamin E, and β-carotenes. This study aimed to clarify the influence of PO plus photobiomodulation (PBM) on leukaemia (K562 cells) proliferation. Cells were treated with various concentrations of PO, PBM at wavelength 655 nm with 1, 2, 3 and 6 J/cm 2 , and PO in pre-and post-irradiation with PBM. The proliferation of cells was investigated by MTT assay, morphologic microscopy and flow cytometry. The amount of reactive oxygen species (ROS) was also determined. Cells were subjected to PO and then PBM in the presence of NAC (N-acetylcysteine) to assess the involvement of ROS in cell growth. PO can diminish the viability of K562 cells significantly. PBM did not have a remarkable effect on the viability of cells. Pre-treatment with PO and then irradiation with 1 J/cm 2 energy could induce apoptosis through intracellular ROS generation and had effective antiproliferative impacts on cells compared to those which acquired separate treatments with laser irradiated alone or PO alone. Thus, our research offers new strategies to utilise PO in combination with PBM in cancer treatment.

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Section: Growth Rates Of K562 Cells In the Presence Of Po Or/and Pbmsupporting

confidence: 92%

Antiproliferative Effects of Palm Oil in the Presence of Photobiomodulation Against K562 Cancer Cells

HEKMAT¹

2023

JOPR

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“…On the palm phytonutrient research front, several studies were published on the mechanisms of action by tocotrienols in inhibiting breast cancer cell growth both in vitro and in vivo. Loganathan et al (2021) reported that tocotrienols have exhibited anti-proliferative effects on human breast cancer cells by promoting programmed cell death or apoptosis possibly through the inactivation and down-regulation of two significant markers: poly-(ADP)-ribose polymerase-1 (PARP-1) and cyclooxygenase-2 (COX-2). In a breast cancer mice model, gamma-tocotrienol supplementation suppresses the growth of breast cancer tumour, as well as metastasis (Subramaniam et al, 2021a).…”

Section: P R E S Smentioning

confidence: 99%

OIL PALM ECONOMIC PERFORMANCE IN MALAYSIA AND R&D PROGRESS IN 2021

KADIR¹

2022

JOPR

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The palm oil industry fared better in 2021 compared to 2020, despite lower crude palm oil (CPO) production due to labour shortage and a restricted supply of CPO during the COVID-19 pandemic. As the industry recovers, research and development (R&D) activities remain dedicated towards ensuring the industry is sustainable and competitive. In the upstream sector, efforts continue to be focused in increasing the CPO yield per hectare through precision agriculture, advanced genomic technologies and improved breeding programmes, control of pest and diseases, as well as farm mechanisation. In the midstream sector, there were some improvements in mill productivity, that reduce the environmental impact of the milling operations.Intensification of R&D related to palm-based biomass has the potential to contribute to higher income for the industry. In the downstream sector, food safety and the nutrition-rich value of palm oil offer the best quality for this versatile and productive oil crop, to the world. Additionally, non-food products such as biofuels, biopolymers and bio-lubricants are also gaining research traction due to global movement towards a circular economy and sustainability.

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“…Tocotrienols are established as natural bioactive compounds with the ability to reduce cancer risk (Aggarwal et al, 2019). The latest findings by Loganathan et al (2020d) portrayed the functionality of palm tocotrienols to exert anti-proliferative and proapoptotic effects based on the manifestation of poly-(adenosine diphosphate)-ribose polymerase (PARP-1) cleavage and cyclooxygenase-2 (COX-2) inactivation of human breast cancer cells. A systematic review on the safety and neuroprotective efficacy of palm oil and tocotrienols-rich fractions (TRF) by Ismail et al (2020a) inferred that the role of palm TRF or alpha-tocotrienol (α-T3) stimulates the cognitive performance of healthy animal and cognitive functions.…”

Section: P R E S Smentioning

confidence: 99%

OIL PALM ECONOMIC PERFORMANCE IN MALAYSIA AND R&D PROGRESS IN 2020

Parveez¹,

Tarmizi²,

Sundram³

et al. 2021

JOPR

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The year 2020 faced unprecedented challenge for most of the global economic growth due to the outbreak of Coronavirus disease . Despite a downward trend performance of the Malaysian oil palm industry, particularly for the first half of 2020, the impact is less severe due to the encouraging palm oil export revenue through the National Economic Recovery Plan (PENJANA) which nurtures a notable increase in crude palm oil (CPO) price. In honouring the Malaysian pledge on forest conservation, land expansion for the oil palm cultivation remains stagnant over the years. The effort is now shifting towards enhancing the oil palm yield performance through new planting materials and good agricultural practices, coupled with systematic pest and disease management. Sustainability continues to be the key agenda of the oil palm industry, in moving forward to sustain the industry ecosystem. The industry is now open for innovative palm oil processes to comply with the dynamic and stringent food safety and quality standards and trade regulations. Owing to the distinction in food and feed applicability together with health prospects, translating the information into consumer-friendly language is becoming crucial for effective communication. Valorisation via the concept of 'waste to wealth' has compelled series of innovations in capitalising oil palm co-products for greener bioenergy and oleochemicals, and source of phytonutrients to generate higher earnings without having to heavily rely on palm oil trade as commodity. Mandatory enactment of the Malaysian Sustainable Palm Oil (MSPO) certification scheme has portrayed a success story of showing the utmost commitment towards sustainability. With persistent dedication, the oil palm industry is envisaged to be self-sustaining, amidst the never-ending challenges surrounding economy, well-being and environment.

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Palm Tocotrienols Cause Cleavage of Poly-(Adp)-Ribose Polymerase Enzyme and Down-Regulation of Cyclooxygenase-2 Protein Level in Human Breast Cancer Cells

Cited by 6 publications

References 17 publications

Antiproliferative Effects of Palm Oil in the Presence of Photobiomodulation Against K562 Cancer Cells

Antiproliferative Effects of Palm Oil in the Presence of Photobiomodulation Against K562 Cancer Cells

OIL PALM ECONOMIC PERFORMANCE IN MALAYSIA AND R&D PROGRESS IN 2021

OIL PALM ECONOMIC PERFORMANCE IN MALAYSIA AND R&D PROGRESS IN 2020

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