Palm Oil in Lipid-Based Formulations and Drug Delivery Systems

Goon, Danial Efendy; Kadir, Siti Hamimah Sheikh Abdul; Latip, Normala Abd; Ab‐Rahim, Sharaniza; Mazlan, Musalmah

doi:10.3390/biom9020064

Cited by 29 publications

(14 citation statements)

References 113 publications

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“…El aceite de coco, contiene un 90.00% de ácidos grasos saturados, donde el 60.00% son ácidos grasos de cadena media 23 como láurico (49.00%), caprílico (8.00%) y cáprico (7.00%). 24 Mientras que en el aceite de palmiste, tiene un 82.00% de ácidos saturados y un 50.00% de su composición son ácidos grasos de cadena media 25 como láurico (48.00%), cáprico (3.50%), caprílico (3.30%) y caproico (0.20%). 26 A continuación, en la Tabla 2 se muestran algunos alimentos que son fuente de ácidos grasos de cadena media.…”

Section: Tabla 1 áCidos Grasos De Cadena Corta De Algunas Fuentes Dietéticasunclassified

Ácidos grasos de cadena corta y media como precursores para inhibir los síntomas del coronavirus

Mateos-Islas

Ventura-Pérez

Ariza‐Ortega

2021

ICSA

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Los ácidos grasos de cadena corta (acético C2:0, propiónico C3:0 y butírico C4:0) y media (caproico C6:0, caprílico C8:0, cáprico C10:0 y láurico C12:0), se originan por la fermentación de la ingesta de fibra en la dieta, llevada a cabo por los microorganismos en el tracto intestinal, y se encuentra en algunos alimentos, su consumo ejerce un efecto antiinflamatorio y antiviral, en virtud de que reducen la expresión de citocinas proinflamatorias como TNF-α, IL-6 e IL-12 y la mediación de IL-10 y son antimicrobianos contra hongos, virus y bacterias debido a que destruyen su membrana celular respectivamente. El objetivo de este trabajo fue revisar el efecto de los ácidos grasos de cadena corta y media, como precursores para inhibir los síntomas del coronavirus. Se ha realizado una búsqueda bibliográfica a través de bases de datos electrónicas y estudios han demostrado que los C2:0, C3:0 y C4:0 a una concentración de 200 mM, 50 mM y 5 mM respectivamente, reducen la inflamación mediante la activación de varios GPCR, que suprimen la expresión de moléculas de adhesión en células inflamatorias y células endoteliales, previniendo la quimiotaxis de monocitos en el sitio inflamatorio. Mientras que el C12:0 a 250 mM es antimicrobiano e inhibe la etapa de maduración tardía del ciclo de replicación del virus. En conclusión, la ingesta de C2:0, C3:0, C4:0 y C12:0 podría disminuir o inhibir los síntomas de la familia del coronavirus, como es el COVID-19.

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Section: Tabla 1 áCidos Grasos De Cadena Corta De Algunas Fuentes Dietéticasunclassified

Ácidos grasos de cadena corta y media como precursores para inhibir los síntomas del coronavirus

Mateos-Islas

Ventura-Pérez

Ariza‐Ortega

2021

ICSA

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“…The utilization of palm oil in the drug nanocarrier and delivery system increased drug biocompatibility, bioavailability and solubility, function as a stabilizing agent, as well as improved drug permeability and shelf life. Besides, the palm oil lipid-based nanoformulation can overcome the issue of high toxicity, poor bioavailability, and poor solubility of several drugs [75]. Palm oil matrices in the form of CPO and CPKO are used as the oil phase in this formulation, and the list of drugs that have been subjected to research is listed in Table 1.…”

Section: Palm Oil Lipid-based Nanoformulation As a Carrier Systemmentioning

confidence: 99%

An Overview of the Oil Palm Industry: Challenges and Some Emerging Opportunities for Nanotechnology Development

2020

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The increase in the world’s oil demand due to the rise of the global population urges more research into the production of sustainable vegetable oilseeds, among which palm oil is the most suitable candidate as it is the most efficient oilseed crop in the world. In an effort to drive the oil palm industry in the areas of food safety and security nanotechnology could offer a sustainable alternative. However, the utilization of nanotechnology in the oil palm industry is still limited. In this review, we aim to encourage the researchers to fully utilize nanotechnology as an alternative solution to tackle the challenges faced by the oil palm industry. Moreover, we also aim to highlight the opportunities for nanotechnology development in oil palm-based related research. The major points are as follows: (1) Nanosensing enables real-time monitoring of plantation status and crop progression, including soil, water and nutrient management, early pest/disease detection, and the spreading of pests/diseases. The use of nanosensing conveniently extends into advanced breeding topics, such as the development of disease-tolerant plants; (2) Nanotechnology could be the answer for the development of integrated management of pest and disease. Active agricultural ingredients can be entrapped or encapsulated into nanocarrier systems to improve their solubility, stability, enhance their efficient delivery to site-specific targets, with longer shelf life, and consequently improved efficacy; (3) Valuable nanomaterials can be isolated and generated from oil palm biomass waste. The utilization of oil palm biomass waste could overcome the issue of the massive production of waste in the oil palm industry and palm oil mills, where oil only accounts for 10% of the biomass, while 90% is comprised of the generated biowastes. (4) Palm oil can be utilized as a green alternative as a capping and stabilizing agent in the biosynthesis of metallic and non-metallic nanoparticles. In addition, nanoemulsion formulations using palm oil in drug delivery systems offer advantages such as low toxicity, enhance bioavailability and solubility of the drugs, apart from being inexpensive and environmentally friendly.

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“…Once ingested, LCT is digested enzymatically before being absorbed by enterocytes and transported into the circulatory system. However, MCT has shown to be readily absorbed and transported directly into the liver through the portal vein to be further metabolised 29 – 31 .…”

Section: Introductionmentioning

confidence: 99%

Untargeted serum metabolites profiling in high-fat diet mice supplemented with enhanced palm tocotrienol-rich fraction using UHPLC-MS

Goon

Ab‐Rahim

Sakri

et al. 2021

Sci Rep

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Excessive high fat dietary intake promotes risk of developing non-alcoholic fatty liver disease (NAFLD) and predisposed with oxidative stress. Palm based tocotrienol-rich fraction (TRF) has been reported able to ameliorate oxidative stress but exhibited poor bioavailability. Thus, we investigated whether an enhanced formulation of TRF in combination with palm kernel oil (medium-chain triglycerides) (ETRF) could ameliorate the effect of high-fat diet (HFD) on leptin-deficient male mice. All the animals were divided into HFD only (HFD group), HFD supplemented with ETRF (ETRF group) and HFD supplemented with TRF (TRF group) and HFD supplemented with PKO (PKO group). After 6 weeks, sera were collected for untargeted metabolite profiling using UHPLC-Orbitrap MS. Univariate analysis unveiled alternation in metabolites for bile acids, amino acids, fatty acids, sphingolipids, and alkaloids. Bile acids, lysine, arachidonic acid, and sphingolipids were downregulated while xanthine and hypoxanthine were upregulated in TRF and ETRF group. The regulation of these metabolites suggests that ETRF may promote better fatty acid oxidation, reduce oxidative stress and pro-inflammatory metabolites and acts as anti-inflammatory in fatty liver compared to TRF. Metabolites regulated by ETRF also provide insight of its role in fatty liver. However, further investigation is warranted to identify the mechanisms involved.

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Palm Oil in Lipid-Based Formulations and Drug Delivery Systems

Cited by 29 publications

References 113 publications

Ácidos grasos de cadena corta y media como precursores para inhibir los síntomas del coronavirus

Ácidos grasos de cadena corta y media como precursores para inhibir los síntomas del coronavirus

An Overview of the Oil Palm Industry: Challenges and Some Emerging Opportunities for Nanotechnology Development

Untargeted serum metabolites profiling in high-fat diet mice supplemented with enhanced palm tocotrienol-rich fraction using UHPLC-MS

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