Palliative Treatment of Recurrent Rectosigmoidal Neoplasms with Two Million Volt Radiation

Wise, Robert E.; Smedal, Magnus I.

doi:10.1016/s0039-6109(16)35803-0

Cited by 7 publications

(6 citation statements)

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“…Overall symptomatic response was reported in 17 articles and ranged from 56% to 100%. Three studies reported 100% responses for bleeding [18,21,35]. …”

Section: Resultsmentioning

confidence: 99%

“…However, Soleimani et al concluded that nominal single dose equivalents (NSDE) between 1000 and 1300 rets was the optimal range [19]. Three retrospective studies reported that the proportion of patients with longer response durations was greater among those who had received higher doses [25,35,36], although they could not document a statistically significant dose-response relationship. In contrast, James et al found the same median duration of response both for those patients given < 15 Gy and those given ≥ 15 Gy.…”

Section: Resultsmentioning

confidence: 99%

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Palliative pelvic radiotherapy of symptomatic incurable rectal cancer – a systematic review

et al. 2013

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Background.Locally advanced and recurrent rectal cancers frequently cause pelvic morbidity including pain, bleeding and mass effect. Palliative pelvic radiotherapy is used to relieve these symptoms and delay local progression. There is no established optimal radiotherapy regimen and clinical practices vary. Our aim was to review the efficacy and toxicity of palliative pelvic radiotherapy of symptomatic rectal cancer and to evaluate different fractionation schedules, based on published literature.Material and methods.Systematic literature searches of Medline, Embase and Cochrane databases were performed through 2011. Studies reporting symptomatic response or quality of life (QOL) after palliative radiotherapy for rectal or rectosigmoid cancer were eligible.Results.Twenty-seven studies were included, of which 23 were retrospective reviews. There were no patient-reported outcomes or QOL assessments. There were large variations in applied radiotherapy regimens. Pooled overall symptom response rate was 75% and positive responses were reported for pain (78%), bleeding and discharge (81%), mass effect (71%) and other pelvic symptoms (72%). Toxicity results were not evaluable.Conclusion.Palliative pelvic radiotherapy for symptomatic rectal cancer appears to provide relief of a variety of pelvic symptoms, although there is no documented optimal radiotherapy regimen in this context. There is inadequate evidence regarding onset, duration and degree of symptom palliation, QOL and associated toxicity with this treatment and prospective studies are therefore needed.

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“…Overall symptomatic response was reported in 17 articles and ranged from 56% to 100%. Three studies reported 100% responses for bleeding [18,21,35]. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Palliative pelvic radiotherapy of symptomatic incurable rectal cancer – a systematic review

et al. 2013

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“…Wise and Smeda [24] reported severe diarrhea in 3 of 22 patients, dysuria and urinary frequency in 2 of 22 patients, and slight nausea in 3of 22 patients.…”

Section: Cancer O F the Colon And Rectummentioning

confidence: 93%

“…Wise and Smedal [24] noted a prolongation of pain relief from an average of 3 y2 to 28 weeks concurrent with increasing dosage from 3,000 r to 6.000 r. Wang and Schultz [21] increased the incidence o f pain relief from 12% (3/24) to 58% (7/12) by increasing the dose from 2,000 r to 4,100-5,000 r.…”

Section: Cancer O F the Colon And Rectummentioning

confidence: 97%

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Radiation Therapy for Patients with Metastatic Cancer Primary in the Breast, Colon or Ovary

Parker¹

1970

Oncology

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1. For patients who are potentially curable of cancer of the breast, colon or ovary, radiotherapy can be an effective adjuvant to surgery. The accomplishments of such treatment include: control of regional tumor spread; reduction of metastases incident to manipulation; conversion of a few patients from being inoperable to being operable. Data documenting the contributions of modern radiotherapy are scarce. 2. For patients who, by current knowledge, are not curable of cancer of the breast, colon or ovary, radiotherapy can be an effective palliative agent. Good usage requires specific indications and contraindications, modern techniques, minimization of treatment-produced morbidity, cost and inconvenience.

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Rectum

Scherer¹

1972

Handbuch Der Medizinischen Radiologie / Encyclopedia of Medical Radiology

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Palliative Treatment of Recurrent Rectosigmoidal Neoplasms with Two Million Volt Radiation

Cited by 7 publications

References 0 publications

Palliative pelvic radiotherapy of symptomatic incurable rectal cancer – a systematic review

Palliative pelvic radiotherapy of symptomatic incurable rectal cancer – a systematic review

Radiation Therapy for Patients with Metastatic Cancer Primary in the Breast, Colon or Ovary

Rectum

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