Palliative resection of the primary tumour in patients with Stage IV colorectal cancer: systematic review and meta‐analysis of the early outcome after laparoscopic and open colectomy

Yang, Timothy X.; Billah, Baki; Morris, David L.; Chua, Terence C.

doi:10.1111/codi.12256

Cited by 10 publications

(5 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…low mortality outlier status was also not closely related between elective and nonelective colorectal practice. 18 As an observational study, this work cannot explain why the observed differences have arisen. the strength of this study derives from its use of a large population-based data set, with the associated relative lack of reporting bias that may be found in voluntary clinical databases.…”

Section: Discussionmentioning

confidence: 78%

Outlier Identification in Colorectal Surgery Should Separate Elective and Nonelective Service Components

Byrne

Mamidanna

Vincent

et al. 2014

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 78%

Outlier Identification in Colorectal Surgery Should Separate Elective and Nonelective Service Components

Byrne

Mamidanna

Vincent

et al. 2014

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

show abstract

“…In recent years, many studies have explored the value of palliative PTR in improving survival. Although their results were controversial, most of these studies reported prolonged OS obtained from palliative PTR [ 20 – 23 ]. However, nearly all data concerning PTR of colorectal cancer were from studies of colorectal adenocarcinoma, as it is the main histological type of colorectal tumors.…”

Section: Discussionmentioning

confidence: 99%

Palliative primary tumor resection may not offer survival benefits for patients with unresectable metastatic colorectal neuroendocrine neoplasms, one multicenter retrospective cohort study

Yu,

Liu,

Wang

et al. 2024

BMC Surg

View full text Add to dashboard Cite

Background The efficacy of palliative primary tumor resection (PTR) in improving prognosis for patients with unresectable metastatic colorectal neuroendocrine neoplasms (NENs) has not been fully explored. Methods We performed one retrospective cohort study and recruited 68 patients with unresectable metastatic colorectal NENs from two Chinese medical centers between 2000 and 2022. All patients were assigned to PTR group and no PTR group. The clinicopathological manifestation data were carefully collected, and the survival outcomes were compared between the two groups using Kaplan–Meier methods. Propensity score matching (PSM) was conducted to minimize confounding bias. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify prognostic factors. Results A total of 32 patients received PTR, and the other 36 patients did not. The median progression-free survival (PFS) and overall survival (OS) times were 4 and 22 months in the whole cohort, respectively. For patients who received no PTR, the median OS was 16 months, and the 1-year OS rate and 3-year OS rate were 56.4% and 39.6%, respectively. For patients who received PTR, the median OS was 24 months, and the 1-year OS rate and 3-year OS rate were 67.9% and 34.1%, respectively. However, the Kaplan–Meier survival curves and log-rank test demonstrated no significant survival difference between the two groups (P = 0.963). Moreover, palliative PTR was also not confirmed as a prognostic factor in subsequent univariable and multivariable Cox proportional hazards regression analyses in both the original and matched cohorts. Only histological differentiation was identified as an independent prognostic factor affecting PFS [hazard ratio (HR) = 1.86, 95% confidence interval (CI): 1.02–3.41, P = 0.043] and OS [HR = 3.70, 95% CI: 1.09–12.48, P = 0.035] in the original cohort. Conclusions Palliative PTR may not offer survival benefits for patients with unresectable metastatic colorectal NENs.

show abstract

“…In recent years, many studies have explored the value of palliative PTR in improving survival. Although their results were controversial, most of these studies reported prolonged OS obtained from palliative PTR [19][20][21][22] . However, nearly all data concerning PTR of colorectal cancer were from studies of colorectal adenocarcinoma, as it is the main histological type of colorectal tumors.…”

Section: Discussionmentioning

confidence: 99%

Palliative primary tumor resection may not offer survival benefits for patients with unresectable metastatic colorectal neuroendocrine neoplasms, one multicenter retrospective cohort study

Wang

Ren²,

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: The efficacy of palliative primary tumor resection (PTR) in improving prognosis for patients with unresectable metastatic colorectal NENs has not been fully explored.Methods: We performed one retrospective cohort study and recruited 68 patients with metastatic colorectal NENs from two Chinese medical centers. The clinicopathological manifestation data were carefully collected, and the survival outcomes were compared between the two groups.Results: A total of 32 patients received PTR, and the other 36 patients did not. The median progression-free survival (PFS) and overall survival (OS) times were 4 and 20 months in the cohort, respectively. For patients who received no PTR, the median OS was 31 months, and the 1-year OS rate and 3-year OS rate were 61% and 42.5%, respectively. For patients who received PTR, the median OS was 24 months, and the 1-year OS rate and 3-year OS rate were 70.5% and 27.9%, respectively. However, the Kaplan–Meier survival curves and log-rank test demonstrated no significant survival difference between the two groups (P=0.585). Palliative PTR was also not confirmed as a prognostic factor in subsequent univariable and multivariable analyses.Conclusions: Palliative PTR may not offer survival benefits for patients with unresectable metastatic colorectal NENs.

show abstract

Palliative resection of the primary tumour in patients with Stage IV colorectal cancer: systematic review and meta‐analysis of the early outcome after laparoscopic and open colectomy

Abstract: Palliative colectomy performed laparoscopically is associated with a better perioperative outcome than open colectomy. Survival is dependent on the response to systemic chemotherapy.

Cited by 10 publications

References 56 publications

Outlier Identification in Colorectal Surgery Should Separate Elective and Nonelective Service Components

Outlier Identification in Colorectal Surgery Should Separate Elective and Nonelective Service Components

Palliative primary tumor resection may not offer survival benefits for patients with unresectable metastatic colorectal neuroendocrine neoplasms, one multicenter retrospective cohort study

Palliative primary tumor resection may not offer survival benefits for patients with unresectable metastatic colorectal neuroendocrine neoplasms, one multicenter retrospective cohort study

Contact Info

Product

Resources

About