Palliative resection for colorectal carinoma

Joffe, Jacobo; Gordon, Philip H.

doi:10.1007/bf02603417

Cited by 106 publications

(81 citation statements)

References 10 publications

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“…There is a high rate of postoperative mortality (12-14%) and morbidity (60%). 48,49 Surgery is often incomplete with persistent and second local recurrence rates of 50 -62%. 50 However, 25% of carefully selected patients who undergo complete resection of tumor can be salvaged and are long-term survivors.…”

Section: Discussionmentioning

confidence: 99%

Long‐term results of reirradiation for patients with recurrent rectal carcinoma

Mohiuddin

Marks

2002

Cancer

188

136

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An adaptive extremum seeking control scheme for a class of nonlinear distributed parameter systems is presented. It addresses the real‐time optimization of a parallel chemical reaction system in an isothermal tubular reactor with uniform distributed feed described by a set of hyperbolic partial differential equations. Only limited knowledge of the kinetics is assumed. An adaptive learning technique is introduced to design an extremum seeking algorithm that drives the system states to a set point that maximizes the value of an objective function. Lyapunov's stability theorem is used in the design of the extremum seeking controller structure and the development of the parameter learning laws. © 2006 American Institute of Chemical Engineers AIChE J, 2006

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Section: Discussionmentioning

confidence: 99%

Long‐term results of reirradiation for patients with recurrent rectal carcinoma

Mohiuddin

Marks

2002

Cancer

188

136

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“…Surgery to manage acute symptoms of bleeding, obstruction and perforation has been advocated for this group. However, the management of asymptomatic patients with stage IV colorectal cancer remains controversial 2,3 . Patient-dependent factors (performance status, co-morbid disease) and extent of distant metastasis are among the considerations that impact on the decision to proceed with surgical management in such patients.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic resection of advanced colorectal cancer

Verheijen

Stevenson

Lumley

et al. 2010

British Journal of Surgery

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“…Both trials demonstrated a statistically significant survival advantage for patients treated with surgery (11.1 vs. 8.1 months, P 5 0.05; 17 vs. 7 months, P 5 0.03, respectively) [14,15]. Longer survival rates have also been shown in studies of gastric cancer [16][17][18][19], ovarian cancer [20], and colorectal carcinoma [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Management of the intact breast primary in the setting of metastatic disease

Bermas

Khan

2009

Breast Cancer Online

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Women who present with new breast cancer and synchronous metastases have traditionally been treated with systemic agents, with no specific therapy for the primary tumor unless local symptoms require palliation. However, a number of retrospective analyses of survival outcomes in these patients show that surgery for the primary tumor is associated with prolongation of survival. These studies suggest the possibility that local therapy for the primary tumor provides value beyond palliation of symptoms and points to the need for prospective data to guide treatment plans for women with de novo metastatic breast cancer. The coherence of the available data is improved by the findings that surgical resection of the primary tumor is of value only when free surgical resection margins are achieved, and that maintenance of local control at the primary site is associated with a survival advantage. Nevertheless, many questions remain, including the optimal timing of surgery for the primary tumor, whether the potential benefit applies only to women with favorable metastatic sites (e.g. bone-only metastases), and whether local radiotherapy should follow surgical treatment of the primary tumor if this is elected. There is also a lack of data addressing the value of axillary surgery in the metastatic setting. These substantial knowledge gaps limit our ability to deploy optimal use of therapeutic modalities for a patient population that reaches large numbers world-wide, and among whom survival duration is increasing due to more effective systemic therapy.

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Palliative resection for colorectal carinoma

Cited by 106 publications

References 10 publications

Long‐term results of reirradiation for patients with recurrent rectal carcinoma

Long‐term results of reirradiation for patients with recurrent rectal carcinoma

Laparoscopic resection of advanced colorectal cancer

Management of the intact breast primary in the setting of metastatic disease

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