Palliative radiotherapy in plasma cell myeloma

Adamietz, I. A.; Schöber, Christian; Schulte, R.; Peest, D.; Renner, K

doi:10.1016/0167-8140(91)90144-6

Cited by 49 publications

(43 citation statements)

References 17 publications

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“…Concurrent chemotherapy or the administration of bisphosphonates had only a slight influence on the reduction of pain. This corresponds with data from the literature [3,15,20] with the exception of the data of Adamietz et al and Mose et al [1,23]. The effect of the radiation dose on the relief of pain is a matter of debate in the literature.…”

Section: Analgesiamentioning

confidence: 89%

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Total and Single Doses Influence the Effectiveness of Radiotherapy in Palliative Treatment of Plasmacytoma

et al. 2008

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Radiotherapy is a very effective palliative treatment. Patients with a reduced general condition, with multiple bone lesions and a poor prognosis profit from short-term schemes (e.g., 1 x 8 Gy to 10 x 3 Gy). Patients in good general condition with a life expectancy of > 1 year and an osteolysis at risk of fracture, should be treated with doses up to 40-50 Gy (20-25 x 2 Gy), in order to achieve the best possible recalcification and pain relief.

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Section: Analgesiamentioning

confidence: 89%

“…Chemotherapy alone has proven to be insufficient for patients with pain or to treat osteolytic lesions [3,15,20]. By the help of radiotherapy pain response rates of 75-100% [1,3,12,15,20,22,23,27] can be achieved. Recalcification is found in 40-50% of the irradiated plasmacytoma lesions [16,23,24].…”

Section: Introductionmentioning

confidence: 99%

Total and Single Doses Influence the Effectiveness of Radiotherapy in Palliative Treatment of Plasmacytoma

et al. 2008

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“…In plasma cell neoplasms, few data are available regarding the role of radiotherapy on painful and recalcification. Generally radiotherapy pain relief was obtained by radiotherapy in 75-100% of cases [1,23,26,31].…”

Section: Discussionmentioning

confidence: 99%

“…They reported pain relief in 85% of patients (complete and partial); recalcification was obtained in 46.4% of patients, whereas 17.9% showed disease progression. A retrospective multicenter study [1] reported the results of a large cohort of patients with plasma cell myeloma from 19 European and North American centers and analyzed only radiation dose-response effects and prognostic factors for survival, progression to myeloma, and patterns of local failure without pain relief and remineralization analysis.…”

Section: Discussionmentioning

confidence: 99%

Impact of Radiotherapy on Pain Relief and Recalcification in Plasma Cell Neoplasms

et al. 2011

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“…In addition, occasionally soft tissue mass appears in extramedullary tissue, resulting in severe pain and reducing the quality of life. In recent years, surgical consultation has been recommended for MM patients with intractable pain, spinal instability and pathological fractures (8); however, the results of the surgery performed on different sites are not definite. To date, no previous studies have conducted a comparative analysis of different surgical sites of MM patients.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the surgical treatment results for multiple myeloma bone disease of the spine and the long bone/soft tissue

Shen

Ling-xiu

et al. 2018

Oncol Lett

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Abstract. The present retrospective study was designed to compare the pain relief, surgery duration, life quality, survival time and relative prognostic factors in multiple myeloma (MM) bone disease patients with different surgical sites. A total of 65 cases were enrolled and divided into two groups. Group A included patients with lesions located in the spine, while Group B included patients with lesions located in the long bone or soft tissue. Pain relief was measured by the visual analogue scale (VAS), neurological impairment was determined according to Frankel classification, and survival was assessed by the Kaplan-Meier method. Cox regression analysis was also used to estimate the effect of factors on the prediction of survival. The hospitalization time, preoperative duration of symptoms, method of surgery, complications, recurrence and survival time were evaluated and compared retrospectively. Pain relief and improvement of life quality were observed in all the patients in groups A and B. No significant differences were detected for the majority of parameters compared between groups A and B, with the exception of the surgery duration, as well as the postoperative VAS score at 1 and 6 months after surgery. The multivariate Cox regression analysis revealed several risk factors significantly associated with survival, including the preoperative VAS score, postoperative chemotherapy, prothrombin time activity (PTA), albumin, lactate dehydrogenase and urine protein level. In conclusion, surgical treatment was an effective therapeutic method in patients with MM. Postoperative analgesic use should be individualized according to the different surgical sites and postoperative periods. Furthermore, preoperative pain, PTA, albumin, urine protein level and postoperative chemotherapy are associated with prognosis.

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Palliative radiotherapy in plasma cell myeloma

Cited by 49 publications

References 17 publications

Total and Single Doses Influence the Effectiveness of Radiotherapy in Palliative Treatment of Plasmacytoma

Total and Single Doses Influence the Effectiveness of Radiotherapy in Palliative Treatment of Plasmacytoma

Impact of Radiotherapy on Pain Relief and Recalcification in Plasma Cell Neoplasms

Comparative analysis of the surgical treatment results for multiple myeloma bone disease of the spine and the long bone/soft tissue

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