Palliative pain relief and safety of percutaneous radiofrequency ablation combined with cement injection for bone metastasis

Zhao, Wei; Wang, Hui; Hu, Jihong; Peng, Zhaohong; Chen, Jin-Zhou; Huang, Jian-Qiang; Jiang, Yong-Neng; Luo, Gang; Yi, Gen-Fa; Shen, Jin; Gao, Bu-Lang

doi:10.1093/jjco/hyy090

Cited by 35 publications

(31 citation statements)

References 30 publications

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“…Thermal ablation, most often radiofrequency ablation or cryoablation, is used when open surgical treatment is contraindicated. It relies on a direct thermal effect destroying the malignant cells[ 51 , 52 ].…”

Section: Adjuvant Treatment Of Metastatic Bone Diseasementioning

confidence: 99%

Current concepts in the surgical treatment of skeletal metastases

Ehne

Tsagozis

2020

WJO

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Symptomatic metastatic bone disease affects a large proportion of patients with malignant tumours and significantly impairs patients’ quality of life. There are still controversies regarding both surgical indications and methods, mainly because of the relatively few high-quality studies in this field. Generally, prosthetic reconstruction has been shown to result in fewer implant failures and should be preferred in patients with a good prognosis. Survival estimation tools should be used as part of preoperative planning. Adjuvant treatment, which relies on radiotherapy and inhibition of osteoclast function may also offer symptomatic relief and prevent implant failure. In this review we discuss the epidemiology, indications for surgery, preoperative planning, surgical techniques and adjuvant treatment of metastatic bone disease.

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Section: Adjuvant Treatment Of Metastatic Bone Diseasementioning

confidence: 99%

Current concepts in the surgical treatment of skeletal metastases

Ehne

Tsagozis

2020

WJO

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“…We identified 2232 studies in the initial screening, and after evaluating abstracts and full texts, 20 publications were selected for full-text assessment. Eventually, 12 studies [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23] were included in this systematic review (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

Analgesia from percutaneous thermal ablation plus cementoplasty for cancer bone metastases

Sun

Zhang

et al. 2019

Journal of Bone Oncology

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BackgroundThe purpose of this study was to review recent research related to the analgesic effect of ablation therapy combined with cementoplasty, as well as to identify the duration of analgesic effect and risk for cement leaks.MethodsA systematic literature search using PubMed, Web of Science, and annual meeting proceedings of the oncology society and other organizations were conducted.ResultsTwelve retrospective studies met the inclusion criteria. Four of the studies included in the review assessed the changes immediately after treatment. Five studies were subjected to analyses of analgesic effect of combined percutaneous thermal ablation and Cementoplasty at 24 weeks after treatment. Incidences of leakage of bone cement during surgery were detected in 4 out of 12 studies. The change of mean pain scores at 1 days, at 1 week, and at 4 weeks, 12 weeks, and 24 weeks after treatment were −3.90 (95% CI: −4.80 to −3.00), −4.55 (95% CI:−5.46 to −3.64), −4.78 (95% CI: −5.70 to −3.86), −5.16 (95% CI: −6.39 to −3.92), and −5.91 (95% CI: −6.63 to −5.19). The relative risk of cement leakage was 0.10 (95% CI: −6.63 to −5.19).ConclusionsOur systematic review suggested that thermal ablation combined with cementoplasty could be a safe and effective intervention for the management of bone metastases-induced pain.

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“…Fortunately, palliative posterior decompression surgery with stabilization and postoperative multidisciplinary treatment have been shown to be effective in such patients [ 28 , 29 ]. With multidisciplinary therapy in lung cancer, the patient’s survival time can be significantly prolonged [ 30 , 31 ]. In our study, 14 patients received radiotherapy, 8 patients received chemotherapy (4–6 cycles), 7 patients received targeted therapy, and 10 patients received zoledronic acid.…”

Section: Discussionmentioning

confidence: 99%

Posterior Decompression Surgery and Radiofrequency Ablation Followed by Vertebroplasty in Spinal Metastases from Lung Cancer

Zhang¹,

Han²,

Li³

et al. 2020

Med Sci Monit

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Background Spinal metastases can cause metastatic epidural spinal cord compression (MESCC), which can result in neurological dysfunction and impaired quality of life. This study investigated the safety and effectiveness of posterior decompression surgery and radiofrequency ablation followed by vertebroplasty in spinal metastasis from lung cancer. Material/Methods From June 2008 to September 2015, a retrospective analysis was conducted in 15 patients with spinal metastasis from lung cancer. All cases suffered MESCC and underwent posterior decompression surgery to relieve the compression of spinal cord, and had radiofrequency ablation followed by vertebroplasty. All patients received postoperative multidisciplinary therapy. The operative time, blood loss, complications, pain, neurologic deficit, quality of life, and survival were assessed preoperatively and postoperatively. Results Patients were followed from 6 to 56 months. The mean time of operation was 154±50 minutes and the mean blood loss was 210±90 mL. In the pre-operation analysis found the mean visual analogue scale (VAS) was 7.86±0.86. In the post-operation analysis at 3 months, the mean VAS score was 3.51±1.32. The VAS improved significantly (t=7.95, P <0.01). The Frankel grade was improved 1 grade or 2 grades in 14 patients when pre-operation was compared to post-operation. Only 1 patient kept Frankel grade D after surgery. Eight patients with sphincteric dysfunction preoperatively were improved after surgery. The EORTC QLQ-C30 score was 86.13±8.51 preoperatively and 52.21±13.28 postoperatively. The quality of life was improved significantly (t=11.8, P <0.01). The median survival time was 11 months. Conclusions Through posterior decompression surgery and radiofrequency ablation followed by vertebroplasty, the quality of life was improved significantly. This palliative treatment was effective and safe in spinal metastasis from lung cancer.

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Palliative pain relief and safety of percutaneous radiofrequency ablation combined with cement injection for bone metastasis

Abstract: RFA with or without bone cement is safe and effective in the palliative treatment of pain caused by metastatic bone tumors.

Cited by 35 publications

References 30 publications

Current concepts in the surgical treatment of skeletal metastases

Current concepts in the surgical treatment of skeletal metastases

Analgesia from percutaneous thermal ablation plus cementoplasty for cancer bone metastases

Posterior Decompression Surgery and Radiofrequency Ablation Followed by Vertebroplasty in Spinal Metastases from Lung Cancer

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