Palliative Care in Movement Disorders: an Evolving Field

Macchi, Zachary A.; Tarolli, Christopher G.; Kluger, Benzi M.

doi:10.1007/s11910-021-01091-5

Cited by 10 publications

(9 citation statements)

References 101 publications

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“…Palliative care can start long before the expected time of death, by integrating it ‘upstream’, namely by recognizing the needs of patients and family earlier on and throughout the course of the disease [ 16 ]. Palliative care has its origins in cancer care, but is important for all kinds of chronic and progressive diseases, including HD [ 17 ]. Its relevance in addressing needs may increase with increasing severity and progression of the disease, with increasing loss of functional capacity.…”

Section: Introductionmentioning

confidence: 99%

Palliative care in advanced Huntington’s disease: a scoping review

et al. 2023

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Background As Huntington’s disease (HD) is a progressive disease for which there is no cure yet, patients in the advanced stage of HD may benefit from palliative care. Objective To review the literature focusing on palliative care in advanced stage HD, and the level of evidence. Methods Publications between 1993 and October 29th, 2021 from 8 databases (Embase, Web of Science, Cochrane, Emcare, PsycINFO, Academic Search Premier, PMC PubMed Central and Pubmed) were included. The literature was deductively classified based on topics that are part of the definition of palliative care, or as care-related topics that emerged from the literature. Levels of evidence I (high) – V (low) were determined as defined by the Joanna Briggs Institute. Results Our search resulted in 333 articles, 38 of which were included. The literature covered four domains of palliative care: physical care, psychological care, spiritual care, and social care. Four other topics in the literature were: advance care planning, end-of-life needs assessments, pediatric HD care, and need for health care services. Most literature was underpinned by a low level of evidence, except for the topics on social care (Level III-V), advance care planning (Level II-V) and end-of-life needs assessments (Level II-III). Conclusions To deliver adequate palliative care in advanced HD, both general and HD-specific symptoms and problems need to be addressed. As the level of evidence in existing literature is low, further research is essential to improve palliative care and to meet patient’s wishes and needs.

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Section: Introductionmentioning

confidence: 99%

Palliative care in advanced Huntington’s disease: a scoping review

et al. 2023

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“…cognitive impairment (CI) is a prevalent nonmotor symptom of PD (Santangelo et al 2015). CI affects >80% of PD patients and can cause dementia (Macchi et al 2021), thereby affecting many aspects of life and increasing the risk of premature death (Baiano et al 2020). Thus, elucidation of the mechanisms involved in CI among PD patients is urgently needed for better outcomes.…”

Section: Introductionmentioning

confidence: 99%

Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling

Huan

Wang

et al. 2022

Metab Brain Dis

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Paeoniflorin (PF) has numerous benefits, including anti-inflammatory and anti-apoptosis effects. However, it is not clear if it has neuroprotective effects against cognitive impairment (CI) in Parkinson’s disease (PD). Through network pharmacology, we identified probable targets as well as signal pathways through which PF might affect CI in PD. Then, we experimentally validated our findings. The core genes of the protein-protein interactions (PPI) network include MAPK8 (JNK), TP53, CASP3 (caspase-3), postsynaptic density protein-95 (PSD-95) and synaptophysin (SYN). Pathway enrichment analysis revealed that genes involved in apoptosis and mitogen-activated protein kinase (MAPK) signaling were significantly enriched. Because JNK is a key mediator of p53-induced apoptosis, we wondered if JNK/p53 pathway influences the effects of PF against apoptosis in mouse model of PD. Molecular docking analysis showed that PF had good affinity for JNK/p53. The results of the experiments indicated that PF ameliorated behavioral impairments and upregulated the expression of the dopamine (DA) neurons, suppressed cell apoptosis in substantia nigra pars compacta (SNpc) of PD. Additionally, PF improved 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury by inhibiting apoptosis in hippocampal neurons of the CA1 and CA3, and upregulating PSD-95 as well as SYN protein levels. Similar protective effects were observed upon JNK/p53 pathway inhibition using SP600125. Overall, PF improved CI in PD by inhibiting JNK/p53 pathway.

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“…Рухові порушення при ХП можуть привести до значних ускладнень в пересуванні, що протребує застосування допоміжних засобів -тростин, ходунків, колясок, а при повній втраті рухових функцій хворий паралізований та прикутий до ліжка чи інвалідного крісла. На цьому етапі розвитку захворювання хворі потребують особливого догляду для запобігання розвитку пролежнів, забезпечення харчування, гігієничних процедур тощо [26,27].…”

Section: ΄яunclassified

Паліативна Допомога У Веденні Пацієнтів З Хворобою Паркінсона

Растворов¹

2023

GoS

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Хвороба Паркінсона (ХП) – поступово прогресуюче хронічне дегенеративне неврологічне захворювання, пов’язане з дегенерацією і руйнуванням дофамінергічних нейронів чорної субстанції та інших відділів центральної нервової системи, що призводить до моторних та немоторних розладів. Основою лікування ХП є застосування препаратів, що впливають на обмін дофаміну, та реабілітаційних заходів. Паліативна допомога, включно з симптоматичною терапією, при ХП спрямована на лікування симптомів, психосоціальну підтримку та реабілітацію. Метою паліативної допомоги є покращення якості життя хворого.

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Palliative Care in Movement Disorders: an Evolving Field

Cited by 10 publications

References 101 publications

Palliative care in advanced Huntington’s disease: a scoping review

Palliative care in advanced Huntington’s disease: a scoping review

Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling

Паліативна Допомога У Веденні Пацієнтів З Хворобою Паркінсона

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