Palladium-Mediated Synthesis of [Carbonyl-11C]acyl Amidines from Aryl Iodides and Aryl Bromides and Their One-Pot Cyclization to 11C-Labeled Oxadiazoles
Abstract:Positron emission tomography (PET) is a highly valuable
imaging
technique with many clinical applications. The possibility to study
physiological and biochemical processes in vivo also makes PET an
important tool in drug discovery. Of importance is the possibility
of labelling the compound of interest with a positron-emitting radionuclide,
such as carbon-11. Carbonylation reactions with [11C]carbon
monoxide ([11C]CO) has been used to label a number of molecules
containing a carbonyl derivative, such as amides … Show more
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