Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives

Abstract

Linearly fused Retinoids derivatives have been synthesized via a straightforward pathway using palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four step linear approach utilizing iodination, sulfonylation or benzylation or esterfication, palladium- catalyzed Sonogashira cross-coupling and palladium mediated reductive Heck cyclization.