Abstract:Herein, we present a facile synthetic
methodology to
produce a
range of N-(CH2-aryl/alkyl)-substituted N-(pyridin-2-yl)benzamides via palladium-mediated C(sp3)–H bond activation. The N-methyl-N-(pyridin-2-yl)benzamide precursor was first reacted with
palladium(II) acetate in a stoichiometric manner to obtain the key
dinuclear palladacycle intermediates, whose structures were elucidated
by mass spectrometric, NMR spectroscopic, and X-ray crystallographic
studies in detail. The subsequent C(sp3)–H bond
functiona… Show more
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