Palladium(II) thiosemicarbazone complex: Synthesis, structure and application to carbon–oxygen cross-coupling reaction

Thiosemicarbazone Complexes of Transition Metals as Catalysts for Cross-Coupling Reactions

“…Published results of the use of thiosemicarbazone complexes as described above for Cheteroatom coupling reactions are summarised in Table 4. Apart from the above C-N coupling reactions, there has also been one report by Suganthy et al of C-O coupling catalysed by a thiosemicarbazone complex [146]. Thus the coupling of p-cresol with a number of aryl halides containing electron-withdrawing or electron-donating groups could be effected, with moderate to very good yields, in DMF at 80 • C after 12 h in an inert atmosphere using a 1 mol% loading of the catalyst [PdCl(PPh 3 )L] (42), where L is the bidentate N,S-chelating ligand derived from the deprotonation of 3-methyl-thiophene-2-carboxaldehyde thiosemicarbazone (Figure 7).…”

Transition Metal—Catalyzed Cross Coupling Reactions

“…Published results of the use of thiosemicarbazone complexes as described above for Cheteroatom coupling reactions are summarised in Table 4. Apart from the above C-N coupling reactions, there has also been one report by Suganthy et al of C-O coupling catalysed by a thiosemicarbazone complex [146]. Thus the coupling of p-cresol with a number of aryl halides containing electron-withdrawing or electron-donating groups could be effected, with moderate to very good yields, in DMF at 80 • C after 12 h in an inert atmosphere using a 1 mol% loading of the catalyst [PdCl(PPh 3 )L] (42), where L is the bidentate N,S-chelating ligand derived from the deprotonation of 3-methyl-thiophene-2-carboxaldehyde thiosemicarbazone (Figure 7).…”

Reactivity of functionalized thiosemicarbazone complexes towards phosphines

“…These have aroused great interest due to their wide range of applications. Their biological activity depends on the parent aldehyde or ketone [1][2][3]; also, palladium (II) complexes have proved to be useful as catalysts in cross coupling reactions like the Heck and Suzuki-Miyaura cross-coupling reaction [4][5][6][7].…”