O trabalho descreve o isolamento de três novos sesquiterpenóides do extrato metanólico dos galhos de Trichilia claussenii: 14-hidroxielemol, germacra-10(14)-en-9,11,15-triol e germacra-3,10(14)-dien-9,11-diol-4-carbaldeído. Também foram isolados os sesquiterpenos β-eudesmol, criptomeridiol e o triterpeno 22,25-diidroxi-9β,19-ciclolanost-23-en-3-ona. Do extrato diclorometânico das folhas de T. lepidota foram isolados mistura de hidrocarbonetos (C 29 H 60 , C 31 H 64 e C 33 H 68 ), mistura dos sesquiterpenos epóxido de cariofileno e epóxido de humuleno, espatulenol e os esteróides 24-metileno-12β-hidroxicolesterol, 24-metil-12β-hidroxicolest-4-en-3-ona, 3-palmitato de 24-metil-12β-hidroxicolest-5-eno, mistura de 24-metilenocolesterol, campesterol, estigmasterol e β-sitosterol, além de α-tocoferol e fitol. O extrato metanólico forneceu a N-metil-4-hidroxiprolina. As estruturas das substâncias isoladas foram estabelecidas com base em dados espectroscópicos.The methanol extract of stems of Trichilia claussenii yielded three new sesquiterpenoids: 14-hydroxyelemol, germacra-10(14)-en-9,11,15-triol and germacra-3,10(14)-dien-9,11-diol-4-carbaldehyde. Two known sesquiterpenoids β-eudesmol, cryptomeridiol and the triterpenoid 22,25-dihydroxy-9β,19-cyclolanost-23-en-3-one were also isolated. The dichloromethane extract from the leaves of T. lepidota afforded a mixture of hydrocarbons (C 29 H 60 , C 31 H 64 and C 33 H 68 ), a mixture of the sesquiterpenes caryophyllene and humulene epoxides, spathulenol, and a series of sterols: 24-methylene-12β-hydroxycholesterol, 24-methyl-12β-hydroxycholest-4-en-3-one, 24-methylene-12β-hydroxycholest-5-ene-3-palmitate; a mixture of 24-methylenecholesterol, campesterol, stigmasterol and β-sitosterol; besides α-tocoferol and phytol. From the methanol extract it was isolated N-methyl-4-hydroxyproline. The structures of the isolated compounds were determined on the basis of spectroscopic analysis.