Palladium (II) complexes containing substituted thiosemicarbazones. Synthesis, spectral characterization, X-ray crystallography, biomolecular interactions and in vitro cytotoxicity

Anu, D.; Naveen, P.; Rath, Nigam P.; Kaveri, M.V.

doi:10.1016/j.molstruc.2020.127703

Cited by 16 publications

(13 citation statements)

References 56 publications

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“…Similarly, the thiosemicarbazones of 4( N )-substituted 4,6-dimethoxysalicylaldehyde 111a – d reacted with [PdCl 2 (AsPh 3 ) 2 ] with Pd(AsPh 3 ) 2 , and two structures of palladium thiosemicarbazones 112a,b and 113a,b were obtained depending upon the type of substituent ( Scheme 54 ) [ 107 ]. All the complexes indicated their DNA/protein binding ability by using absorption and emission titrations.…”

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

“…Further, AO/EB and DAPI staining methods were carried out to detect the cell death induced by the complexes. Complex 112a exhibited better cytotoxic activity [ 107 ]. The palladium complexes 111a – d were analysed using cell inhibition expressed in IC 50 values and were found as 36 ± 1.0, 27 ± 1.0, 35 ± 1.0 and 29 ± 1.0 for MCF-7 cell lines.…”

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

“…All complexes showed moderate activity compared to the standard cisplatin. In addition, the coordination of the ligands to the Pd(II) ion enhances the antiproliferative activity of the complexes against both cell lines [ 107 ].…”

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

“…Crystallographic studies showed that complexes 112b and 113a distorted square planar geometry around palladium metal ions [ 107 ]. In complex 113a, the palladium (II) ion is coordinated through the thiolate sulphur atom with Pd(1)-S(1) bond distance of 2.246 (5) Å and the nitrogen atom with a Pd(1)-N(1) bond distance of 2.063 (12) Å.…”

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

“…The bond distances and angles between palladium and the coordinated atoms are similar to the reported Pd(II) complexes. In complex 113a , a hydrogen bonding interaction is found with the donor-acceptor distance of 2.580 (17)° corresponding to the N(2)-O(1) [ 107 ].…”

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

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Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

et al. 2023

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: This review focuses on some interesting and recent applications of transition metals towards the complexation of thiosemicarbazides, thiocarbohydrazides, and their corresponding carbazones. We started the review with a description of the chosen five metals, including Cu[Cu(I), Cu(II], Co(II), Ni(II), Pd(II), and Ag(I) and their electronic configurations. The stability of the assigned complexes was also discussed. We shed light on different routes describing the synthesis of these ligands. We also reported on different examples of the synthesis of Cu(I), Cu(II), Co(II), Ni(II), Ag(I), and Pd(II) of thiosemicarbazide and thiocarbohydrazide complexes (until 2022). This review also deals with a summary of the fruitful use of metal complexes of thiosemicarbazones and thiocarbazones ligands in the field of catalysis. Finally, this recent review focuses on the applications of these complexes related to their biological importance.

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Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

Section: Metal Complexes Of Thiosemicarbazones and Thiocarbazonesmentioning

confidence: 99%

See 3 more Smart Citations

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

et al. 2023

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Tetrahydrobiopterin from cyanide‐degrading bacterium Bacillus pumilus strain SVD06 induces apoptosis in human lung adenocarcinoma cell (A549)

Mahendran,

Selvaraj,

Dhanapal

et al. 2023

Biotech and App Biochem

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Tetrahydrobiopterin (BH4) is an essential biological cofactor and a derivative of pterin which is considered potent anticancer agents. In continuation of our previous study on the identification of BH4 from cyanide‐degrading Bacillus pumilus, the present study focuses on evaluating the anticancer properties of BH4 on A549, a human lung adenocarcinoma. Anticancer activity analysis shows that BH4 inhibited A549 cell growth after 24 h of incubation with 0.02 mg/mL. In acridine orange/ethidium bromide staining, BH4‐treated A549 cells showed apoptotic morphology. BH4 treatment caused cell cycle arrest at G0/G1 phase compared to control cells. BH4 augmented p53 expression in alveolar cancer cells by downregulating MDM2 levels. There was downregulation of casp‐3 and upregulation of iNOS gene in BH4‐treated A549 cells. Further, docking studies indicated that BH4 had significant interactions with the above proteins affirming the apoptosis mechanism. Thus, BH4 could be considered a potential anticancer drug.

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Palladium(II) Complexes of 4‐Phenyl‐3‐thiosemicarbazone Ligands: Insights Into Cytotoxic Properties and Mode of Cell Death

Mansour,

Khaled,

Radacki

et al. 2024

Chemistry & Biodiversity

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Reactions between sodium tetrachloropalladate and 2‐ (or 4‐) substituted 4‐phenyl‐3‐thiosemicarbazone ligands (HLR), with various electron‐donating and electron‐withdrawing substituents (R = OCH3, NO2, and Cl), afford square‐planar complexes of the general formula [Pd(LR)2]. Ground‐state geometry optimization and the vibrational analysis of cis‐ and trans‐isomers of the complexes were carried out to get an insight into the stereochemistry of the complexes. Natural bond orbital analysis was used to analyze how the nature of the substituent affects the natural charge of the metal center, the type of hybridization, and the strength of the M−N and M−S bonds. Using spectrophotometry, the stability of the complexes, and their DNA binding abilities were assessed. The Pd(II) complexes showed moderate cytotoxicity against HepG‐2 and Caco‐2 cell lines, two of the assessed malignant cell lines, resulting in all known cell death types, including early apoptotic bodies and late apoptotic vacuoles as well as evident necrotic bodies.

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Palladium (II) complexes containing substituted thiosemicarbazones. Synthesis, spectral characterization, X-ray crystallography, biomolecular interactions and in vitro cytotoxicity

Cited by 16 publications

References 56 publications

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

Tetrahydrobiopterin from cyanide‐degrading bacterium Bacillus pumilus strain SVD06 induces apoptosis in human lung adenocarcinoma cell (A549)

Palladium(II) Complexes of 4‐Phenyl‐3‐thiosemicarbazone Ligands: Insights Into Cytotoxic Properties and Mode of Cell Death

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