Palladium(II)‐Catalyzed CH Bond Arylation of Electron‐Deficient Arenes at Room Temperature

Scope and Limitations of Auxiliary-Assisted, Palladium-Catalyzed Arylation and Alkylation of sp2 and sp3 C–H Bonds

“…1 Regioselective, intermolecular arylation and alkylation of heterocycles and other arenes can be efficiently accomplished by employing first- and second-row transition-metal catalysis. 2 A recent report by Ackerman shows that meta-alkylation of 2-phenylpyridine derivatives is feasible. 2l In contrast, intermolecular functionalization of unactivated (not benzylic or α to heteroatom) sp 3 C-H bonds has attracted less attention.…”

Aerobic Fujiwara–Moritani alkenylation and dienylation of ferrocene

“…Moreover, our system works at room temperature, a condition which is still challenging in Pdcatalyzed CeH bond activation [16]. The reactions described in this work constitute a direct route to mono-and dialkenylated ferrocenes and ferrocenyl-substituted dienes which may be of interest as starting materials in syntheses of more complex ferrocenyl systems.…”

Biaryl Synthesis through Metal‐Catalyzed C–H Arylation

“…Examples include the C-H arylation of arenes bearing carboxylic acids with arylboronic acids [164a] or arylboronates [164b] by Yu, amide-assisted ortho-C-H arylation with aryltrifluoroborates by Shi [165], and C-H/C-B coupling of 2-phenylpyridine with arylboronic acids in the presence of a rhodium [166a] or a palladium catalyst [166b]. Other examples are C-H/C-B coupling using aryl O-methyloximes [167] or aryl carbamates [168] and an ortho-selective coupling of aryl imines with aryltrifluoroborates at room temperature [169]. Carretero [170] reported the C-H arylation of 2-pyridylsulfinylbenzenes under a similar palladium catalytic system.…”