Palladium complexes: new candidates for anti-cancer drugs

Jahromi, Ehsan Zareian; Divsalar, Adeleh; Saboury, Ali Akbar; Khaleghizadeh, Sara; Mansouri‐Torshizi, Hassan; Kostova, Irena

doi:10.1007/s13738-015-0804-8

Cited by 71 publications

(35 citation statements)

References 137 publications

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“…This composition was selected due to the high antimicrobial effect of silver and for the anticancer properties of platinum. 16,17 The antibacterial activity of silver nanoparticles is based on the penetration of the cell membrane, which suppress the respiratory enzyme. 18 Additionally, nanoparticles interfere with the DNA inside the bacteria cells, preventing the replication and transcription of the genetic material.…”

Section: Introductionmentioning

confidence: 99%

<p>Novel Silver-Platinum Nanoparticles for Anticancer and Antimicrobial Applications</p>

Ruiz¹,

Garcia²,

Gallón³

et al. 2020

IJN

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Background: Cancer is a disease with an enormous worldwide impact. One of the fatal complications in cancer patients are bacterial opportunistic infections. The use of chemotherapeutic drugs made cancer remission more frequent and prolonged patient survival, but, increased the risk of infections. Purpose: Address the current problem with growing pandemic cancer and considering high risks of complications with bacterial infections, the present study synthesized novel dendritic assembly of silver (Ag)-platinum (Pt) nanoparticles. Methods: Nanoparticles were characterized by TEM analysis, and the composition was confirmed by EDX. Bacterial studies were performed for Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and Gram-negative multi-drug resistant Escherichia coli. Cell experiments were performed with two different cancer cell lines, glioblastoma and melanoma to determine anticancer activity. Finally, cytotoxicity with fibroblast was tested. Results: The TEM analysis of silver-platinum (AgPt) nanoparticles showed dendrimer shape nanoparticles with a mean size of 42 ± 11nm. Elemental composition was analyzed by EDX, confirming the presence of both Ag and Pt metals. The synthesized nanoparticles significantly inhibited the growth of medically important pathogenic, Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and Gram-negative multi-drug resistant Escherichia coli. Bactericidal effect of AgPt nanoparticles had greater effectiveness than silver nanoparticles. MTS assay revealed a selective and dose-dependent anticancer activity of AgPt nanoparticles over cancer cell lines glioblastoma and melanoma in the 10-250 µg/mL concentration range. Cytotoxicity experiments with fibroblast cells showed no side effects of nanoparticles against healthy cells at a range of concentrations from 10-50 µg/mL. Conclusion: The newly synthesized AgPt nanoparticles have a promising future as a potent anticancer agent with antibacterial properties.

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Section: Introductionmentioning

confidence: 99%

<p>Novel Silver-Platinum Nanoparticles for Anticancer and Antimicrobial Applications</p>

Ruiz¹,

Garcia²,

Gallón³

et al. 2020

IJN

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“…The anticancer activity of cisplatin (cis‐diamminedichloroplatinum(II)) was discovered by Barnett Rosenberg and coworkers in 1969, which has been used extensively for different types of neoplasms including head, neck, ovarian, bladder, endometrial, cervical, testicular, osteogenic sarcoma, and lung cancers . After using cisplatin as an antitumor agent successfully, many other complexes containing platinum or other metals such as, vanadium, ruthenium, copper, iron, cobalt, palladium, rhodium, zinc, and nickel have been proposed with selectivity and cytotoxicity toward tumor cells…”

Section: Introductionmentioning

confidence: 99%

“…[20] The anticancer activity of cisplatin (cis-diamminedichloroplatinum(II)) was discovered by Barnett Rosenberg and coworkers in 1969, [21] which has been used extensively for different types of neoplasms including head, neck, ovarian, bladder, endometrial, cervical, testicular, osteogenic sarcoma, and lung cancers. [22] After using cisplatin as an antitumor agent successfully, many other complexes containing platinum or other metals such as, vanadium, [23] ruthenium [23] , copper, [23] iron, [24] cobalt, [25] palladium, [26] rhodium, [27] zinc, [27] and nickel have been proposed with selectivity and cytotoxicity toward tumor cells. [27] Gold(III) complexes with chelating N-donor ligands are the first gold(III) complexes examined for anticancer applications, [28] in vitro pharmacological studies point out that some of these novel gold(III) complexes are highly cytotoxic toward cultured human tumor cell lines, [29] pyridine-based complexes were tested in vitro against a panel of cancer cell lines and HeLa cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and anticancer activity of some azole‐heterocyclic complexes with gold(III), palladium(II), nickel(II), and copper(II) metal ions

Abdnoor

Alabdali

2019

J Chinese Chemical Soc

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Four new complexes of Au(III), Pd(II), Ni(II), and Cu(II) ions were synthesized, derived from a novel heterocyclic ligand (L) that has both triazole and tetrazole rings. The ligand synthesis was through successive steps to achieve both heterocyclic rings. The synthesized compounds were characterized using conventional techniques like infrared, ultra violet—visible and proton/carbon nuclear magnetic resonance spectroscopy, metal and thermal analyses, and molar conductivity. All complexes were suggested to have square planar geometry, gold, nickel, and palladium complexes were salts while copper neutral complexes have the chemical formulas; [AuL2]Cl.2H2O, [PdL2]Cl2.2H2O, [NiL2]Cl2.2H2O, and [CuL2]. The cytotoxic effect was studied on breast cancer cell line (MCF‐7 cell line) at different concentrations by using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay method, for the ligand (L) and complexes. The results showed that gold(III) and nickel(II) complexes have the highest cytotoxicity among all compounds against cancer cell lines.

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“…[13][14][15] However, it has side effects such as nephrotoxicity, drug tolerance, limited solubility and intravenous administration. [14,[16][17][18][19] Due to the fact that the cancer is the second leading cause of death, [16,20,21] the development of improved metal based drugs is currently of interest.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and cytotoxic activity of tioconazole coordination compounds with nickel(II), palladium(II) and platinum(II)

Barba¹,

Crisóstomo-Lucas

Navarro-Peñaloza

et al. 2019

J. Mex. Chem. Soc.

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Coordination compounds of nickel(II), palladium(II) and platinum(II) with tioconazole (tcnz) were synthesized and characterized by infrared, UV-Vis-NIR, elemental analysis, molar conductivity, magnetic susceptibility, mass spectrometry, NMR spectroscopy and X- ray diffraction. Tioconazole presented a monodentate coordination mode, through the nitrogen atom of the imidazolic ring. The NiII compounds stabilized an octahedral geometry. In [Ni(tcnz)2(NO3)2].H2O the coordinated nitrate presented a bidentate coordination mode, while for the [Ni(tcnz)2(OAc)2].3H2O compound, the acetate behaves as a bridging ligand. When different molar ratios were used on the reaction synthesis, three or six ligands were coordinate to the nickel(II) atom, [Ni(tcnz)3Br2(H2O)], [Ni(tcnz)6]Cl2 and [Ni(tcnz)6]Br2. The palladium(II) and platinum(II) compounds, [Pd(tcnz)2Cl2], [Pt(tcnz)2Cl2].2H2O and [Pd(tcnz)2(OAc)2], stabilized a trans-square planar geometry. The compounds [Ni(tcnz)6]X2 give place to 3D supramolecular arrangements through hydrogen bonding (X∙∙∙H, X = Cl and Br) and p∙∙∙p stacking interactions, between the six membered rings of neighbouring molecules. The in vitro cytotoxic activity of the synthesized compounds was studied in four different human carcinoma cell lines: HCT-15 (colon), HeLa (cervix-uterine), MCF-7 (breast) and PC-3 (prostate).

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Palladium complexes: new candidates for anti-cancer drugs

Cited by 71 publications

References 137 publications

<p>Novel Silver-Platinum Nanoparticles for Anticancer and Antimicrobial Applications</p>

<p>Novel Silver-Platinum Nanoparticles for Anticancer and Antimicrobial Applications</p>

Synthesis, characterization, and anticancer activity of some azole‐heterocyclic complexes with gold(III), palladium(II), nickel(II), and copper(II) metal ions

Synthesis, characterization and cytotoxic activity of tioconazole coordination compounds with nickel(II), palladium(II) and platinum(II)

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