Palladium-Catalyzed α-Arylation of Meyers’s Chiral Bicyclic Lactams and a Deprotonative Ring-Opening Sideline
Hsin-Lun Chiang,
Wei-Ting Zhao,
Yen-Ku Wu
et al.
Abstract:Described is a deprotonative α-arylation reaction of Meyers’ chiral bicyclic lactams (MCBLs) under palladium catalysis, and a substrate-dependent post-transformation. When the bridgehead carbon of the MCBLs is substituted with a methyl or an ethyl group, the initial arylation product undergoes a further rearrangement reaction to give a conjugated framework. On the other hand, the substrates bearing a bridgehead-isopropyl or an aryl group are converted into the corresponding exo-arylation products. Preliminary … Show more
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