Palladium‐catalyzed synthesis of novel pyrido[3,4‐d]pyridazin‐1(2H)‐ones as promising α‐glucosidase, α‐amylase and EGFR inhibitors along with molecular docking
Abstract:A novel route has been established for the synthesis of novel pyrido [3,4-d]pyridazin-1(2H)-one derivative. Synthesis of intermediate 4-methyl-7-(piperazin-1-yl)pyrido [3,4-d]pyridazin-1(2H)-one carried out in the presence of Pd(PPh 3 ) 2 Cl 2 catalyst. Ten novel derivatives were synthesized, isolated, and characterized by various spectroscopic techniques. All synthesized molecules were screened for in silico parameters and evaluated for α-glucosidase and α-amylase inhibitory assay. Furthermore, all synthesize… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.