Palladium-Catalyzed, Site-Selective C(sp2)8–H Halogenation and Nitration of 4-Quinolone Derivatives
Tapas Kumar Das,
Prasanjit Ghosh,
Shibaji Ghosh
et al.
Abstract:Selective installation of halo and nitro groups in heterocyclic backbone through a transition-metal-catalyzed C−H bond activation strategy is immensely alluring to access high-value scaffolds. Here in, we disclosed N-pyrimidyl-directed assisted palladium(II)-catalyzed C(sp 2 )8−H halogenation and nitration of substituted 4-quinolone derivatives in the presence of Nhalosuccinimide and tert-butyl nitrite, respectively, offering structurally diversified 8-halo/nitro-embedded 4-quinolone frameworks in high yields.… Show more
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