Palladium-Catalyzed intramolecular Cyclization of ‘2-bromo-1,5- di-ene-7-yne’System: A Versatile Route to the Poly-ene Substituted Cyclohexenols

Abstract

A general and efficient methodology has been developed for the synthesis of substituted cyclohexenol system with conjugated bis-exocyclic diene via Pd-catalyzed intramolecular 6-exo-dig cyclization of 'ene-yne' moiety. This method is straight forward and high yielding.