Palladium-catalyzed cross-coupling reactions constitute one of the most important and useful transformations in transition metal-catalyzed reactions [1][2][3]. Although this research field emerged in the 1970s, it is still attracting considerable attention in synthetic and organometallic chemistry. New catalysts and catalytic systems are being developed to further expand the utility of the reactions. This Special Issue on "Palladium Catalysts for Cross-Coupling Reaction" covers the diverse aspects of the ever-evolving field of palladium catalysts in cross coupling chemistry.This issue includes three reviews and three articles. The review by Ohashi and Ogoshi summarizes the recent development of palladium-catalyzed cross-coupling reactions of perfluoro organic compounds, such as tetrafluoroethylene and hexafluorobenzene [4]. One of the key steps of the reactions is the oxidative addition of a C-F bond to palladium(0). The finding that lithium iodide promotes the step, led the authors' to develop efficient cross-coupling with organozinc reagents. The reactions with boronates are also presented. The review by Manabe and Yamaguchi covers the Pd-catalyzed cross-coupling reactions in which the site-selectivities between the two halo groups of dihaloarene substrates were controlled by the catalysts used [5]. Some new ligands for palladium were designed to realize high selectivity. This synthetic strategy is now a powerful tool for efficient synthesis of multi-substituted arenes. Obora and Ishii summarize recent progress in palladium-catalyzed oxidative amination of alkenes with amines, using O2 as the terminal oxidant [6]. In this review, the uses of palladium catalysts combined with molybdovanadophosphate as a co-catalyst under O2 are presented. In addition, the interesting results of amination using O2 as the sole oxidant are also provided. In the article by Sajiki and Monguchi et al., a successful example of continuous flow Suzuki-Miyaura coupling reactions of haloarenes with arylboronic acids is described [7]. Only 20 s were required for the single-pass flow through a cartridge filled with palladium on carbon to afford the desired coupling products in high yields. Takanami et al. developed a synthetic method of pentafluorophenyl-and related polyfluorophenyl-substituted porphyrins [8]. By choosing the appropriate palladium catalyst OPEN ACCESS