2019
DOI: 10.1039/c9cc05233j
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Palladium-catalyzed enol/enolate directed oxidative annulation: functionalized naphthofuroquinone synthesis and bioactivity evaluation

Abstract: Diverse naphthoquinone-containing heterocycle synthesis has been developed via enol/enolate-directed palladium catalytic processes together with late-stage functionalization and lead compound development.

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Cited by 7 publications
(3 citation statements)
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“…In 2019, Wang and co‐workers synthesized naphthofuroquinone derivatives 95 and 96 from annulations of 2‐hydroxy‐1,4‐naphthoquinone 94 with internal alkynes 2 (Scheme 45). [48] For this purpose, they designed two reaction conditions. For the synthesis of 1,2‐naphthofuroquinones 95 , Pd(II) was served as a catalyst, oxone/benzoquinone (BQ) as oxidants and the reaction was carried out under O 2 .…”
Section: Transition Metal‐catalyzed Transformations Of Diaryl/alkyl A...mentioning
confidence: 99%
“…In 2019, Wang and co‐workers synthesized naphthofuroquinone derivatives 95 and 96 from annulations of 2‐hydroxy‐1,4‐naphthoquinone 94 with internal alkynes 2 (Scheme 45). [48] For this purpose, they designed two reaction conditions. For the synthesis of 1,2‐naphthofuroquinones 95 , Pd(II) was served as a catalyst, oxone/benzoquinone (BQ) as oxidants and the reaction was carried out under O 2 .…”
Section: Transition Metal‐catalyzed Transformations Of Diaryl/alkyl A...mentioning
confidence: 99%
“…Inspired by this result, they decided to investigate the reaction scope, employing several meta-substituted N-phenyl 2-trimethylsilylethynylbenzamides 47, bearing electrondonating and electron-withdrawing groups (R = H, Me, F, Br and Cl), and the respective products 48 were obtained in very good yields. In the same year, Wang, Sun, and co-workers reported the Pd(II)-catalyzed Oxonemediated oxidative sequential addition-annulation of 1,2-naphthofuroquinones 49 with diaryl alkynes 50, to prepare functionalized naphthofuroquinones 51 (Scheme 32) [37]. The method was efficiently applied to several functionalized 2-hydroxy-1,4-naphthoquinones 49, bearing electron-neutral, -donating, and -withdrawing aryl substituents.…”
Section: Oxygen-containing Heterocyclesmentioning
confidence: 99%
“…89 In 2019, Sun, Wang, and co-workers presented a palladium-catalyzed oxidative annulation of naphthoquinones with internal alkynes(Scheme 21c). 90…”
Section: Scheme 20 Synthesis Of Dibenzofurans Via Rh Catalysismentioning
confidence: 99%