Palladium‐Catalyzed Chemoselective Mono‐α‐Arylation of O‐Protected Hydroxyacetone with Ortho‐Substituted (Hetero)aryl Electrophiles

Abstract

The mono‐α‐arylation of 2‐tetrahydropyranyl O‐protection of hydroxyacetone is reported. When using a catalyst system comprised of [Pd(cinnamyl)Cl]2 and the JosiPhos ligands PhPF‐tBu or (4‐CF3Ph)PF‐tBu, such transformations are achieved with ortho‐substituted aryl bromides and triflates in the presence of potentially contending functionalities including chloro groups.