Palladium-catalyzed carbonylation with direct indole C-H activation involving HCFO-1233zd (E)
Xiao Zhao,
Wen Zhu,
Yu Jing
et al.
Abstract:3-Idolenone is a key intermediate in the synthesis of many drugs and
plays an important role in synthetic chemistry and biochemi-stry. A new
method for the synthesis of trifluoromethylated 3-indolenones by
carbonylation reaction catalyzed by Pd (0) is de-scribed. In the absence
of an additive, 1-chloro-3,3,3-trifluoro-propylene (a cheap
ozone-friendly CF3 structural unit) reacts with indole and carbon
monoxide to synthesize trifluoromethylatedindolenone, good yield,
Regioselectivity and Chemoselectivity, and s… Show more
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