Palladium-catalyzed C–H dimethylamination of 1-chloromethyl naphthalenes with N,N-dimethylformamide as the dimethyl amino source

Abstract

Palladium-catalyzed remote C−H dimethylamination of 1-chloromethylnaphthalenes using N,N-dimethylformamide as the dimethylamino source is described for the first time. The dimethylamination took place exclusively on the 4-position of 1-chloromethylnaphthalenes in 2-methyltetrahydrofuran...