Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

Abstract

Heterocyclic compounds are commonly found in the core structures of several pharmaceuticals, natural products, and agrochemicals, thus spurring intensive research for conducting their synthesis in a mild and simpler way. Over the years, a host of different strategies has been introduced in an effort to synthesize these heterocyles. In this context, significant attention has been gained by methodologies that ensure both step as well as atom efficiency. Synthesis of heterocyclic moieties via multiple C-H activations was found to fulfill these expectations besides guaranteeing the use of starting materials that are easily procurable. This review is focused on the current development in the field of benzofuran and indole synthesis using multiple C-H functionalization strategies.

Recent Progress in the Transition Metal Catalyzed Synthesis of Indoles

“…For instance, NHC/Pd catalyst was proven efficient in this reaction (Scheme 28) [53]. The reaction showed some interesting features: reaction for the synthesis of nitrogen heterocycles [5,7,9,11,13]. In the last two years, other methodologies have appeared in the literature.…”

“…Moreover, transition metal catalyzed cross-coupling reactions involving C-H activation are an alternative strategy to the traditional synthetic protocol and have recently increased importance for the construction of C-C and C-N bonds [4][5][6][7][8][9][10][11][12][13][14].…”

One-pot synthesis and property study on thieno[3,2-b]furan compounds

“…2 Therefore, more and more attention has been paid to the design and synthesis of this type of compounds. [7][8][9][10][11][12][13][14][15] Over the years, some synthetic methods including transition metal catalyzed intramolecular C-O coupling [16][17][18] and bis-C/Hactivated ring closure of diaryl ethers 19,20 as well as ring closure of ortho-hydroxyarylalkynes [21][22][23][24][25][26][27] have been reported for the synthesis of furan-fused ring compounds. These methods are usually high-yielding and applicable to a variety of substrates.…”

Sustainable Protocol for Benzylic -CH2Oxidation with Dioxygen to Phenones Using AuNPs@ Resin Beads

“…Acetophenone and its derivatives are highly valuable chemicals in industry as important feedstocks for the manufacturing of bulk chemicals, polymers, pharmaceuticals, agrochemicals etc . Industrially, acetophenone is synthesized by Friedel‐Crafs acylation of arenes using acyl halides or acid anhydrides in presence of Lewis acids or by oxidation of alkyl arenes using stoichiometric amount of chemical reagents.…”