Palladium-Catalyzed Benzodiazepines Synthesis

Christodoulou, Michael S.; Beccalli, Egle M.; Giofrè, Sabrina

doi:10.3390/catal10060634

Cited by 14 publications

(4 citation statements)

References 103 publications

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“…The method allows the formation of indoline and oxindole derivatives as well as polyheterocyclic molecules [2a] . A wide range of approaches are available in the synthesis of benzodiazepines including hydroamination, amination, C−H arylation, N ‐arylation, and the Buchwald–Hartwig reaction induced either by Pd 0 or Pd II catalysts [2b] …”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis of Five‐membered Nitrogen Heterocycles Induced by Palladium Ions and Complexes

Molnár

2023

ChemistrySelect

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This review aims to collect and analyze recent results with respect to the use of varied palladium preparations in the synthesis of five-membered nitrogen heterocycles including condensed derivatives. Results have been selected with focus on studies of the last three years. Furthermore, a common feature of all methods treated here is that the nitrogencontaining five-membered ring is formed via ring closing of appropriate starting materials. Selected examples discussed will reveal that a plethora of products from small monocycles to condensed multi-ring systems can be successfully accessed. Major features are wide product ranges, high product yields and stereoselectivities often achieved under mild reaction conditions.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis of Five‐membered Nitrogen Heterocycles Induced by Palladium Ions and Complexes

Molnár

2023

ChemistrySelect

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“…Although already described in 1929 by Le Fèvre, [11] only limited reports for the construction of 1,3‐diazepines are known. Despite considerable recent synthetic efforts in this area, [1d,3a,b,d,12–26] the synthesis of functionalized 1,3‐diazepine derivatives remains a challenging task. Therefore, better synthetic routes to the 1,3‐diazepine framework from readily available starting materials are desirable.…”

Section: Introductionmentioning

confidence: 99%

2,2′‐Bis(arylamino)‐1,1′‐biaryls as Building Blocks for the Synthesis of Dibenzo[d,f][1,3]diazepines, Dibenzo[d,f][1,3]diazepinones, and Dibenzo[c,e][1,2,7]thiadiazepine 6‐Oxides

Thoran,

Schuh,

Holling

et al. 2023

Eur J Org Chem

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The iron‐catalyzed oxidative C−C homocoupling of diarylamines affords 2,2′‐bis(arylamino)‐1,1′‐biaryls which represent crucial synthetic building blocks for an access to a range of seven‐membered heterocyclic ring systems. Reaction with paraformaldehyde, diphenyl carbonate, and diphenyl sulfite as efficient 1,1‐dielectrophiles led to dibenzo[d,f][1,3]diazepines, dibenzo[d,f][1,3]diazepinones, and dibenzo[c,e][1,2,7]thiadiazepine 6‐oxides. The synthetic procedures enable short and practical routes to these 1,3‐diazepine derivatives under mild reaction conditions and with a high tolerance of various functional groups.

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“…[ 36 ] Another review was reported on the synthesis of benzodiazepines through palladium catalysis. [ 37 ]…”

Section: Introductionmentioning

confidence: 99%

An overview of palladium‐catalyzed synthesis of seven‐membered heterocycles

Saranya

Neetha

Radhika

et al. 2020

Journal of Heterocyclic Chem

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Heterocyclic compounds are the ones that have always remained in the limelight owing to their superior contributions toward various disciplines such as biology, medicine, material science, pharmaceutical science, industry and so on. They form the building blocks of DNA and RNA macromolecules. Suitable tuning of these heterocyclic compounds can result in chemotherapeutic moieties with superlative efficiency. Seven‐membered heterocyclic compounds are an important class of heterocyclic chemistry. Some of them are azepine, oxepine, thiepine, diazepine, thiazepine and so on. Transition metal‐catalyzed synthesis of heterocycles has been the most explored in the recent past. Palladium is known as the best suitable catalyst for the same and that is the result of its excellent functional group tolerance and catalytic potency. Here, we intend to summarize the various investigations made on the palladium‐catalyzed synthesis of seven‐membered heterocycles. To the best of our knowledge, this is the first review in this topic and covers literature up to 2020.

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Palladium-Catalyzed Benzodiazepines Synthesis

Cited by 14 publications

References 103 publications

Recent Advances in the Synthesis of Five‐membered Nitrogen Heterocycles Induced by Palladium Ions and Complexes

Recent Advances in the Synthesis of Five‐membered Nitrogen Heterocycles Induced by Palladium Ions and Complexes

2,2′‐Bis(arylamino)‐1,1′‐biaryls as Building Blocks for the Synthesis of Dibenzo[d,f][1,3]diazepines, Dibenzo[d,f][1,3]diazepinones, and Dibenzo[c,e][1,2,7]thiadiazepine 6‐Oxides

An overview of palladium‐catalyzed synthesis of seven‐membered heterocycles

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