Palladium-catalyzed Asymmetric Allylic Alkylation UsingC2-symmetric Chiral Bidentate Bis(N-heterocyclic carbene) Ligands with theo-Xylylene Framework

Yamaguchi, Yoshitaka; Suzuki, Yasuhiro; Matsumoto, Shimpei; Anezaki, Satoshi; Asami, Masatoshi

doi:10.1246/cl.160235

Cited by 5 publications

(1 citation statement)

References 44 publications

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“…Biscarbene ligands have been rarely used because of the lowto-moderate enantioselectivities (ee values up to 81%) reported for the benchmark Pd-catalyzed allylic alkylation of rac-1,3diphenylallyl acetate with dimethyl malonate 172,173. …”

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Recent Advances in Enantioselective Pd-Catalyzed Allylic Substitution: From Design to Applications

Pàmies

Margalef

Cañellas³

et al. 2021

Chem. Rev.

369

202

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This Review compiles the evolution, mechanistic understanding, and more recent advances in enantioselective Pd-catalyzed allylic substitution and decarboxylative and oxidative allylic substitutions. For each reaction, the catalytic data, as well as examples of their application to the synthesis of more complex molecules, are collected. Sections in which we discuss key mechanistic aspects for high selectivity and a comparison with other metals (with advantages and disadvantages) are also included. For Pd-catalyzed asymmetric allylic substitution, the catalytic data are grouped according to the type of nucleophile employed. Because of the prominent position of the use of stabilized carbon nucleophiles and heteronucleophiles, many chiral ligands have been developed. To better compare the results, they are presented grouped by ligand types. Pd-catalyzed asymmetric decarboxylative reactions are mainly promoted by PHOX or Trost ligands, which justifies organizing this section in chronological order. For asymmetric oxidative allylic substitution the results are grouped according to the type of nucleophile used.

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confidence: 99%