Palladium‐Catalyzed Annulation of 2‐(1‐Alkynyl)benzenamines with Disulfides: Synthesis of 3‐Sulfenylindoles

Abstract

3-Sulfenylindoles can be efficiently prepared in moderate to good yields from 2-(1-alkyn-

AgSbF6‐Catalyzed Tandem Reaction of 2‐Alkynylanilines with Cyclic Enynones: Efficient access to 3‐Furo[3,2‐c]chromenylindoles and Related Scaffolds

“…Furthermore, in 2015, an interesting domino reaction between 2‐alkynylanilines and p ‐quinone methides as electrophiles using PdCl 2 as a catalyst for the synthesis of unsymmetrical diarylindolymethanes was established by Anand et al . Besides the above successes, investigations towards other electrophiles such as aldehydes,– phosphine oxides, disulphides, isocyanates, cyclopropanes, selectfluor,– diazoacetates etc have also emerged in this annulation‐functionalization process using Ag I /Au III /Pd II /Rh I ‐salts as efficient catalysts, leading to the corresponding 2,3‐dfunctionalized indoles. The main advantage of the above protocols is that they exclude the isolation and purification of the generated 2‐substituted indoles and excel with wider substrate scope.…”

Synergistic Cooperative Effect of Sodium borohydride‐Iodine Towards Cascade C−N and C−S/Se Bond Formation: One‐pot Regioselective Synthesis of 3‐Sulfenyl/selenyl Indoles and Mechanistic Insight

“…Similarly, Zhang et al provides another route for synthesis of 3‐sulfenylindoles by palladium‐catalyzed annulation of 2‐(1‐alkynyl)benzenamines with disulfides as a sulphur source (Scheme ). At times, the high cost and the toxicity of transition metals limits the utility of many synthetic routes.…”

Convenient and Efficient Synthesis of Functionalized 2-Sulfenylindoles

“…There are many efficient methodologies for the synthesis of sulfenylindoles reported in the literature [ 20 , 21 , 22 , 23 , 24 , 25 ]. Among them, the direct sulfenylation of indoles is one of the most efficient and common strategies [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”