Palladium Catalysis: Dependence of the Efficiency of C−C Bond Formation on Carboxylate Ligand and Alkali Metal Carboxylate or Carboxylic Acid Additive. Part C: The Domino Diarylation and Annelation Reactions

Abstract

The efficiency of the formation of C–C bonds under palladium catalysis often depends on the nature of the carboxylate ligand and carboxylic acids or alkali metal carboxylates additives. This review which is Part C of a trilogy devoted to the topic, highlights the influence of the carboxylate units on domino diarylation and annelation reactions. The plausible reaction mechanisms are presented with, as far as possible, personal comments.

Palladium Catalysis: Dependence of the Efficiency of C–N Bond Formation on Carboxylate Ligand and Metal Carboxylate or Carboxylic Acid Additive

“…The efficiency of the Pd(OCOR) 2 -catalyzed C–C bond formation may greatly depend on the carboxylate ligand and metal carboxylate or carboxylic acid additive, as highlighted in a number of reports. 1 Such dependences of the C–N bond formation of reactions leading to anilines or oxidative amination, hydroamination, transamidation, and annelation 2 products are the subject of the present Mini-Review, which is not exhaustive and discards the processes with amino acid additives. We will tentatively clarify the role of the carboxylate unit and the effect of its characteristics on the reaction efficiency.…”