Palladium and platinum complexes of folic acid as new drug delivery systems for treatment of breast cancer cells

He, Chenyang; Majd, Mostafa Heidari; Shiri, Fereshteh; Shahraki, Somaye

doi:10.1016/j.molstruc.2020.129806

Cited by 26 publications

(21 citation statements)

References 42 publications

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“…Using MTT assay on MCF-7 breast cancer cells, it was observed that this complex had improved cytotoxicity and induced apoptosis more potently compared to cisplatin, additionally enhancing its cellular uptake. Molecular docking confirmed that the platinum complex may form a very stable complex with folate receptors [ 30 ].…”

Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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“…For a few decades, the identification of new cytotoxic compounds led to the beginning of new therapeutic compounds that are used to treat a variety of carcinomas . It is noteworthy that less than 40 agents were used routinely in the clinical stage over 600,000 compounds in the testing phase due to the limitation of their application as anticarcinoma drugs . The application of various anticancarcinoma drugs used to treat carcinomas is limited due to their severe side defects like cisplatin, which have several undesirable effects on patients suffering from carcinomas due to their haphazard toxicity to the brain, drug resistance, low stability, and low solubility in physiological media .…”

Section: Introductionmentioning

confidence: 99%

One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

et al. 2021

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The physicochemical approaches and biological principles in bio-nanotechnology favor specially functionalized nanosized particles. Cuprous oxide nanoparticles (β-Cu2O NPs) of cuprite phase with a little tenorite (CuO) may be very effective in the development of novel therapeutic approaches against several fatalities including A-549 lung carcinoma cell lines. Consequently, the synthesis of β-Cu2O NPs for the improvement in the therapeutic index and drug delivery application is becoming an effective strategy in conventional anticarcinoma treatment. Hence, surface-enhanced nanosized spherical cuprous oxide nanoparticles (β-Cu2O NPs) of cuprite phase were successfully prepared using poly(ethylene glycol) (PEG) as an amphiphilic nonionic surfactant and l-ascorbic acid (K3[Cu(Cl5)]@LAA-PEG) reduced to cuprites β-Cu2O NPs via the sonochemical route. Less improved toxicity and better solubility of β-Cu2O NPs compared with Axitinib were a major reason for producing β-Cu2O NPs from K3[Cu(Cl5)]@LAA-PEG (LAA, l-ascorbic acid, PEG, poly(ethylene glycol) (PEG)). These nanoparticle syntheses have been suggested to influence their cytotoxicity, free-radical scavenging analysis, and reactive oxygen species (ROS) using poly(ethylene glycol) (PEG) and l-ascorbic acid (LAA) as coated and grafted materials due to their dose-dependent nature and IC50 calculations. The surface morphology of the formed β-Cu2O NPs has been examined via UV–vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy with energy diffraction scattering spectroscopy (SEM@EDS), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM) analysis. X-ray diffraction (XRD) and Brunauer–Emmett–Teller (BET) surface analysis results confirm the presence of pure cuprite with a very little amount of tenorite (CuO) phase, Dynamic light scattering (DLS) confirms the negative ζ-value with stable nature. Docking was performed using PDB of lung carcinomas and others, as rigid receptors, whereas the β-Cu2O NP cluster was treated as a flexible ligand.

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“…The 1,10‐phenanthroline zinc(II) dichloride complex was synthesized according to previous work. [ 11 ] In summary, ZnCl 2 (1.36 g, 10 mmol) was dissolved in 50 ml of distilled water at 60°C; then, NaCl (2.92 g, 50 mmol), HCl (100 μl), and 1,10‐phenanthroline (1.82 g, 10 mmol) were added to the reaction mixture and stirred overnight at 45°C. Finally, the obtained product was filtered through Whatman filter paper, washed with distilled water, and dried in an oven at 50°C.…”

Section: Methodsmentioning

confidence: 99%

“…The output trajectory of MD simulation was used in molecular docking simulation. [ 11 ] The grid size was set for blind docking of the complex with FR at 100 × 100 × 105 Å in the x , y , and z axes, respectively, with 0.375‐Å grids spacing to cover the whole receptor. With default settings for the protein, Smina was run to sample nine complex conformations using the Vina docking routine of Monte Carlo stochastic sampling.…”

Section: Methodsmentioning

confidence: 99%

“…[ 9 ] In addition, it has been confirmed that FA can affect the expression of some genes, including the Bcl‐2 oncogene protein, and induce apoptosis. [ 10,11 ] All of these data suggest that FA may play an important role in targeting cancerous tumors as well as increasing apoptosis, so its use as a ligand in complex synthesis may reduce the dose of the drug in patients with cervical cancer and provide optimal treatment.…”

Section: Introductionmentioning

confidence: 99%

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The in vitro apoptotic effect of new zinc complex possessing folic acid and phenanthroline on cervix cancer cells

Yang

Majd

Shiri

et al. 2021

Applied Organom Chemis

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With proper care and nursing as well as timely diagnosis and good treatment, cervical cancer is one of the most treatable forms of cancer. One of the most important cancer treatments is the use of emerging developing metal–organic complexes, which can provide a wide variety of morphologies, sizes, and properties based on different metal ions and different organic ligands. Accordingly, we reported the synthesis method, structural properties, cytotoxicity, apoptotic properties, and molecular docking analysis of the new Zn(II) complex consisting of phenanthroline and folic acid ligands. FTIR, 1H‐NMR, 13C‐NMR, and elemental analyzer determined that the synthesis of the complex was successful. The IC50 values (380 and 199 μM) were shown that the viability of HeLa cells was dependent on time of exposure and concentration of [Zn(Phen)FA] complex. Real‐time PCR clearly shows increased expression of apoptotic genes in cervical carcinoma HeLa cells and a possible relationship between Bak1/Bclx ratio and caspase‐3. Also, the key amino acids of folate receptor that can interact with the synthesized complex were identified by molecular docking analysis. Moreover, molecular electrostatic potential confirmed that carboxylate portion of FA is an electron‐rich region and can interact with Zn(Phen) to form a stable and soluble complex. All experiments confirmed that presence of FA could improve stability, cytotoxicity, apoptosis, and cellular uptake of complex in cervical carcinoma HeLa cells.

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Palladium and platinum complexes of folic acid as new drug delivery systems for treatment of breast cancer cells

Cited by 26 publications

References 42 publications

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

The in vitro apoptotic effect of new zinc complex possessing folic acid and phenanthroline on cervix cancer cells

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Palladium and platinum complexes of folic acid as new drug delivery systems for treatment of breast cancer cells

Cited by 26 publications

References 42 publications

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

One-Pot Surface Modification of β-Cu2O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

The in vitro apoptotic effect of new zinc complex possessing folic acid and phenanthroline on cervix cancer cells

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One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis