“…Further, the carboxylic group of amino acids opens up the possibility of site-specific functionalization via decarboxylative pathway. Transition metal-catalyzed decarboxylative coupling reaction provides an ecofriendly pathway for C–C or C–heteroatom bond formation due to in situ formation of organometallic species. − This involves relatively neutral conditions and eliminates expensive and toxic organometallic reagents. , Various decarboxylative Csp 3 –Csp 3 , Csp 3 –Csp 2 , and Csp 3 –Csp couplings − have been reported to synthesize a wide range of value-added chemicals including propargylamines, biaryls, , 2-alkynylbuta-1,3-dienes, 1,4-diamino-2-butynes, 1,2,3-triazoles, etc. Recently, we reported decarboxylative A3 and KA2 coupling strategies for one-pot multicomponent reactions to afford a wide range of propargylamines and C1-alkynylation of tetrahydroisoquinolines and N-heterocycles using CuO@Fe 2 O 3 MNPs and Cu@SiO 2 –NS as recyclable nanocatalysts, respectively. , To date, there are very few reports describing the decarboxylative tandem coupling among proline, aldehydes, and alkynes using Cu-salts as homogeneous catalysts. − There is a need to develop efficient nanocatalysts for these decarboxylative tandem coupling reactions under green and sustainable conditions.…”