Palladin is a novel microtubule-associated protein responsible for spindle orientation

Zhang, Xiang; Chen, Xinlei; Liu, Jing; Xu, Xin; Zhang, Yuanliang; Ruan, Zheng; Xie, Yinyin; Huang, Qiu-Hua; Tong, Yin; Chen, Zhu; Chen, Sai‐Juan

doi:10.1038/s41598-017-12051-w

Cited by 3 publications

(3 citation statements)

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“…After interrogating the SKI and TAZ interactomes against each other, it was found that the interactions which overlap between the two are predominantly involved in actin cytoskeleton remodelling. Palladin (PALLD), WASH Complex Subunit 5 (WASHC5, or KIAA0196), and Capping Protein Regulator and Myosin 1 Linker 2 (CARMIL2, formerly RLTPR) were found in both interactomes, and are all involved in F-actin polymerization and stabilization[441][442][443][444] . Pathway enrichment analysis revealed that the SKI interactome showed moderate enhancement of Notch signalling, adipogenesis, and autophagy (Fig 4.6C).…”

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confidence: 99%

Periostin in cardiovascular disease and development: a tale of two distinct roles

2017

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Tissue development and homeostasis are dependent upon the concerted synthesis, maintenance, and degradation of extracellular matrix (ECM) molecules. Cardiac fibrosis is now recognized as a primary contributor to incidence of heart failure, particularly heart failure with preserved ejection fraction, wherein cardiac filling in diastole is compromised. Periostin is a cell-associated protein involved in cell fate determination, proliferation, tumorigenesis, and inflammatory responses. As a non-structural component of the ECM, secreted 90 kDa periostin is emerging as an important matricellular factor in cardiac mesenchymal tissue development. In addition, periostin's role as a mediator in cell-matrix crosstalk has also garnered attention for its association with fibroproliferative diseases in the myocardium, and for its association with TGF-β/BMP signaling. This review summarizes the phylogenetic history of periostin, its role in cardiac development, and the major signaling pathways influencing its expression in cardiovascular pathology. Further, we provide a synthesis of the current literature to distinguish the multiple roles of periostin in cardiac health, development and disease. As periostin may be targeted for therapeutic treatment of cardiac fibrosis, these insights may shed light on the putative timing for application of periostin-specific therapies.

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confidence: 99%

Periostin in cardiovascular disease and development: a tale of two distinct roles

2017

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“…In the CNS, palladin is expressed in the neural plate, neural progenitor cells, cortical neurons, and astrocytes [ 38 , 39 , 40 ]. The protein is involved in embryonic development, neuronal maturation, the cell cycle, differentiation, and apoptosis [ 38 , 41 , 42 , 43 ]. The role of palladin in brain tumors is currently unknown.…”

Section: Introductionmentioning

confidence: 99%

Cytoskeletal Protein Palladin in Adult Gliomas Predicts Disease Incidence, Progression, and Prognosis

Mayer

Bugis

Kozlova

et al. 2022

Cancers

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Brain tumors comprise over 100 types of masses, differing in the following: location; patient age; molecular, histological, and immunohistochemical characteristics; and prognosis and treatment. Glioma tumors originate from neuroglia, cells supporting the brain. Palladin, a structural protein widely expressed in mammalian tissues, has a pivotal role in cytoskeletal dynamics and motility in health and disease. Palladin is linked to the progression of breast, pancreatic, and renal cancers. In the central nervous system, palladin is involved in embryonic development, neuronal maturation, the cell cycle, differentiation, and apoptosis. However, the role of palladin in brain tumors is unknown. In this work, we explored palladin’s role in glioma. We analyzed clinical data, along with bulk and single-cell gene expression. We then validated our results using IHC staining of tumor samples, together with qRT-PCR of glioma cell lines. We determined that wild-type palladin-4 is overexpressed in adult gliomas and is correlated with a decrease in survival. Palladin expression outperformed clinically used prognostic markers and was most prominent in glioblastoma. Finally, we showed that palladin originates from the malignant cell population. Our findings indicate that palladin expression might be linked to adult glioma progression and is associated with prognosis.

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“…Adaptive network‐based fuzzy inference system (ANFIS), which has the superiority of both the ANN and the fuzzy inference system, is an effective tool to handle the problems of regression . In ANFIS, fuzzy membership functions and fuzzy rules are obtained through learning large quantities of historical data, rather than human experience or intuition.…”

Section: Introductionmentioning

confidence: 99%

Multi‐Scale Fuzzy Inference System for Influent Characteristic Prediction of Wastewater Treatment

Cheng

Li²,

Bai

et al. 2018

CLEAN Soil Air Water

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Accurate influent characteristic prediction is vital to maintain the stable performance of wastewater treatment processes. In this work, an associated approach based on the wavelet packet decomposition (WPD) and adaptive network‐based fuzzy inference system (ANFIS) is proposed to address this issue. In this method, the WPD is first adopted to decompose the historical data of the influent characteristic into wavelet coefficients in different scales. The time sub‐series, which are obtained with a single branch reconstruction of the wavelet coefficients in each scale, are then utilized to build the ANFIS regression model. The predicted sub‐results in each scale are finally summarized into an eventual predicted result. Moreover, a particle swarm optimization (PSO) algorithm is employed to acquire the optimal parameters of the multi‐scale ANFIS, and chaos theory is utilized to determine the input variables of the multi‐scale ANFIS. The reported approach is investigated by the influent characteristic data, including the chemical oxygen and biochemical oxygen demands from a wastewater treatment plant (WTP) in southwest of China. Two peer models are introduced for a comparison study. The results show that the developed approach has superior performance in terms of the mean absolute error (3.346 and 1.384), mean absolute percentage error (1.804% and 1.800%), root mean square error (3.988 and 1.788), and correlation coefficient (0.960 and 0.964), and can accurately predict the influent characteristic of the WTP.

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Palladin is a novel microtubule-associated protein responsible for spindle orientation

Cited by 3 publications

References 47 publications

Periostin in cardiovascular disease and development: a tale of two distinct roles

Periostin in cardiovascular disease and development: a tale of two distinct roles

Cytoskeletal Protein Palladin in Adult Gliomas Predicts Disease Incidence, Progression, and Prognosis

Multi‐Scale Fuzzy Inference System for Influent Characteristic Prediction of Wastewater Treatment

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