Palisades in Primary Cerebral Neuroblastoma Simulating So-called Polar Spongioblastoma

Polar spongioblastoma: A high‐grade glioma that does not contain the IDH1 mutation or 1p/19q LOH

“…In some of these tumors, both neuronal and glial phenotypes have been detected (Table 1). 14–16 Therefore, making the correct diagnosis is difficult for these cases under the current classification scheme.…”

Polar Spongioblastoma of the Spinal Cord: A Case Report

“…Formerly categorized as a ''tumor of unknown origin,'' it is now referred to instead as a ''growth pattern'' in the most recent World Health Organization classification of CNS tumors [14,15]. This opinion is supported by the observation that a palisaded architecture may be focally detected in a wide variety of other neoplasms, including cerebral neuroblastoma [6,7], fi brillary astrocytoma [5,8,9], ependymoma, pilocytic astrocytoma, oligodendroglioma, and medulloblastoma [8]. Others contend, however, that an entity status is justified in those rare cases where this rhythmic pattern is exclusively represented and associated with a more aggressive biologic behavior, akin to that observed in CNS embryonal tumors [1,4,12,13].…”

“…In keeping with a theoretical origin from spongioblasts/radial glia observed in early development, that original report and others that followed depicted both aggressive behavior and a propensity for craniospinal metastases, features expected of embryonal tumors [1–4]. The status of this lesion as an entity remains in question, however, as focal cellular palisades are occasionally encountered in other, more well-established tumor types including oligodendroglioma, ependymoma, medulloblastoma, cerebral neuroblastoma, and pilocytic and fibrillary astrocytoma [5–9].…”