Palisaded, Encapsulated Neuromas of the Skin

Palisaded encapsulated neuroma of the upper lip

“…The incidence rate of PEN in the oral mucosal biopsy specimens were 0.04% to 0.05% in the previous reports [4,7], and PEN accounts for approximately 22% to 25% of all peripheral nerve origin in the oral cavity [4,7]. The mean age of PEN on the oral mucosa was between 37 to 54 years [3,4,7,8] and it was almost the same tendency that of the skin's as between 40 and 60 years [2]. As for sex difference, men were almost predominant to women [3,7,8].…”

“…The palisaded encapsulated neuroma (PEN) is an uncommon entity, first described as a series of 44 cases of the skin in 1972 by Reed et al [2]. PEN is a hyperplastic lesion, nodular appearance, consisting of Schwann cells with completely/incompletely encapsulated.…”

Palisaded encapsulated neuroma: An uncommon tumour at uncommon location

“…Clinically it is closely simulated by schwannoma, neurofibroma, dermatofibroma, appendageal tumours of skin, epidermal cyst, basal cell carcinoma and intradermal naevi [1,4,7]. Relatively, very lower occurrence of telengienctasia and ulceration helps in ruling out the diagnosis of basal cell carcinoma [4].…”

“…PEN also known as 'solitary circumscribed neuroma' is an uncommon, sporadic, cutaneous, benign, intraneural tumor, which usually presents as asymptomatic, solitary or multiple, firm, rubbery, skin-coloured or pink, papule or nodule, commonly localized on the face or close to a muco-cutaneous junction in middle -aged adults with equal sex preponderance [1]. It was first described by Reed et al in 1972 [1].…”

“…It was first described by Reed et al in 1972 [1]. Being solitary or multiple, it has never been seen to be associated with neurofibromatosis or multiple endocrine neoplasia [2].…”