Paliperidone palmitate-induced facial angioedema: A case report

Srifuengfung, Maytinee; Sukakul, Thanisorn; Liangcheep, Chanika; Viravan, Natee

doi:10.12998/wjcc.v8.i20.4876

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…This was confirmed in the same patient who received risperidone tablets which does not have OROS properties and displayed no adverse reaction. Srifuengfung et al reported an angioedema causing acute laryngeal oedema and respiratory arrest 20 days after the 2nd loading dose of paliperidone LAI [ 6 ]. Notably, however, only two reports documented allergic reactions to paliperidone or risperidone LAI in patients tolerating the oral format.…”

Section: Discussionmentioning

confidence: 99%

“…Paliperidone palmitate, a formulation available as a LAI, can be administered intramuscularly every four weeks. Recently, few studies have reported allergic reactions associated with paliperidone/risperidone intramuscular (IM) injections, ranging in the extent of severity from a mild local reaction to anaphylaxis [ 2 , 6 , 7 ]. As a result, psychiatric guidelines recommend trialling a period of oral paliperidone for 4–5 days prior to administering a LAI [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Long-acting injectable paliperidone palmitate induced severe cutaneous allergic reaction in a patient with first episode delusional disorder tolerating oral paliperidone regimen: a case report

et al. 2022

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Background Paliperidone is a second-generation antipsychotic agent that is effective in the treatment of schizophrenia and schizoaffective disorder as well as an adjunct to mood stabilizers and antidepressants for bipolar and depressive disorders. Paliperidone is available in both oral and injection forms. Here we report an unexpected case of cutaneous allergic reaction induced by paliperidone long-acting injection (LAI) following oral tolerance. Case presentation A 55-year-old man with first episode delusional disorder was treated with paliperidone tablets with tolerance. On day seven he received the paliperidone LAI and developed an allergic reaction in minutes including flushing of the face, widespread urticaria with mild airway constriction. The allergic symptoms were relived following the administration of antihistamine within several minutes. Conclusion The allergic reaction that occurred post administration of the paliperidone LAI but not the oral tablets suggest it is likely due to the excipients in the formulation of the LAI rather than paliperidone itself. This case highlights the necessity of monitoring allergic reactions in psychiatric patients when converting from oral to LAI format of paliperidone.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%