Paliperidone Overdose With Delayed Onset of Toxicity

Levine, Michael P.; LoVecchio, Frank; Tafoya, Paul; Graham, Roger A.

doi:10.1016/j.annemergmed.2010.10.015

Cited by 18 publications

(13 citation statements)

References 9 publications

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“…10 Antagonism of the serotonin a2 and dopamine 2 receptors is responsible for the therapeutic effects on the negative and positive symptoms of schizophrenia, respectively. 9 However, antagonism of the dopamine 2 and serotonin a2 receptors can also lead to extrapyramidal symptoms, restlessness, agitation and akathisia. Antagonism of the histamine 1 receptors results in sedation, whereas antagonism of α1 receptor results in orthostasis and reflex tachycardia.…”

Section: Discussionmentioning

confidence: 99%

“…In the case described by Levine and coll., 9 after ingestion of 180 mg of paliperidone adverse cardiac effect (a narrow complex tachycardia) developed 26.5 h post-ingestion.…”

Section: 413mentioning

confidence: 99%

“…[6][7][8][9][10][11] The first case of paliperidone overdose was described by Chang and coll. 6 in 2010.…”

Section: 413mentioning

confidence: 99%

“…To our knowledge there are few cases of paliperidone intoxication published since its approval. [6][7][8][9][10][11] In the FDA pre-marketing database two mortality cases are reported under paliperidone treatment. 7 Since both of those patients were also under some other medications the relationships between causes of death and the use of paliperidone remained unclear.…”

Section: 413mentioning

confidence: 99%

“…3,4 Other observed side effects were cardiac disorders (various cardiac rhythm disturbances, prolonged QTc interval, orthostatic hypotension), gastrointestinal disorders, anxiety, sleep disorder, headache. 4,5 There are few literature reports of paliperidone overdoses [6][7][8][9][10][11] and its safety in overdose has not been established.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dyskinesia, cardiac arrhythmia and partial seizure associated with paliperidone overdose: a case report

Villa¹,

Gallotta²,

Malaguti³

et al. 2015

Ital J Med

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Paliperidone is a new atypical antipsychotic agent. There are few literature reports of paliperidone overdoses and we report a case of these. A 32-year-old man was admitted to Emergency Department for occurrence of opisthotonus, muscular spasms and rigidity. Twenty hours before, he had an ingestion of 168 mg of paliperidone. He had hypotension and tachycardia. The dystonic reaction completely resolved within a few minutes after diazepam. Nine hours after admission, he sudden showed a right hemisoma partial seizure. The peculiar interest of our case is that three different and rare symptoms occurred in successive times after overdose. Some symptoms occurred after several hours following overdose. Oral paliperidone is available as an osmotic release delivery system that results in a gradual rise in plasma concentrations. According to this limited experience in which delayed onset of toxicity has been observed, it may be prudent to recommend prolonged observation after overdose of paliperidone.

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Section: Discussionmentioning

confidence: 99%

“…In the case described by Levine and coll., 9 after ingestion of 180 mg of paliperidone adverse cardiac effect (a narrow complex tachycardia) developed 26.5 h post-ingestion.…”

Section: 413mentioning

confidence: 99%

“…[6][7][8][9][10][11] The first case of paliperidone overdose was described by Chang and coll. 6 in 2010.…”

Section: 413mentioning

confidence: 99%