Paliperidone-Associated Atrioventricular Block

Yasin, Muhammad; Lateef, Noman; Pervaiz, Mohammad Hassan

doi:10.1097/mjt.0000000000000747

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Paliperidone has a known dose-dependent pro-arrhythmic effect [4]. The high initial loading doses may increase the risk of higher degree AV blocks.…”

Section: Discussionmentioning

confidence: 99%

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Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic

Harrisingh¹,

Cu²,

Le³

et al. 2023

Cureus

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Our case report highlights the importance of understanding various mechanisms of an atrioventricular block (AVB) and recognizing potential iatrogenic culprits. Despite the prevalent use of second-generation antipsychotics and the growing popularity of long-acting formulations, it is not routinely recognized as a cause for AVB. Second-generation antipsychotics such as risperidone have a dose-dependent pro-arrhythmic effect and are known to cause first-degree AVB. Our case presents an opportunity to recognize an unappreciated cause for AVB and switch to safer alternatives. In the era of long-acting injectables, it is important to monitor for these effects prior to escalating doses and risking high-degree AVB.

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“…Paliperidone has a known dose-dependent pro-arrhythmic effect [4]. The high initial loading doses may increase the risk of higher degree AV blocks.…”

Section: Discussionmentioning

confidence: 99%

“…There have been some case reports linking Paliperidone to first-degree AV blocks, but no documented cases with second-degree AV block [ 2 - 3 ]. Paliperidone has a known dose-dependent pro-arrhythmic effect [ 4 ]. The high initial loading doses may increase the risk of higher degree AV blocks.…”

Section: Discussionmentioning

confidence: 99%

Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic

Harrisingh¹,

Cu²,

Le³

et al. 2023

Cureus

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Paliperidone

2019

Reactions Weekly

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First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose

Cheung

Levy

Shivkumar³

2020

European Journal of Case Reports in Internal Medicine

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Background: Paliperidone and mirtazapine are psychotropic agents associated with proarrhythmic effects. Case Presentation: A 21-year-old woman was admitted to the intensive care unit on two separate occasions for attempting suicide by overdosing on paliperidone and mirtazapine. During both admissions, the patient had atypical chest pain and a first-degree atrioventricular block (AVB) with paradoxical sinus tachycardia, which resolved with the discontinuation of paliperidone and mirtazapine and aggressive intravenous fluids. Conclusion: Drug-induced first-degree AVB from paliperidone and mirtazapine should be on the differential diagnosis in patients on paliperidone and/or mirtazapine who present with chest pain, tachycardia or new-onset first-degree AVB

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Paliperidone-Associated Atrioventricular Block

Cited by 3 publications

References 6 publications

Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic

Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic

Paliperidone

First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose

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